NOAEL Studies
Cosmetic Ingredient
Hexyl Alcohol NOAEL Studies
INCI: HEXYL ALCOHOL
CAS: 111-27-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | dog | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1022 | mg/kg bw/day | rat | oral | 1 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1127 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =720 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1007; row=13353; data_type=In Vivo; mixture=Chemical; chemical_name=1-Hexanol; preferred_name=1-Hexanol; dtxsid=DTXSID8021931; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3210 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1008; row=13352; data_type=In Vivo; mixture=Chemical; chemical_name=1-Hexanol; preferred_name=1-Hexanol; dtxsid=DTXSID8021931; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4420 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1009; row=13354; data_type=In Vivo; mixture=Chemical; chemical_name=1-Hexanol; preferred_name=1-Hexanol; dtxsid=DTXSID8021931; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4590 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1010; row=13356; data_type=In Vivo; mixture=Chemical; chemical_name=1-Hexanol; preferred_name=1-Hexanol; dtxsid=DTXSID8021931; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4870 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1011; row=13355; data_type=In Vivo; mixture=Chemical; chemical_name=1-Hexanol; preferred_name=1-Hexanol; dtxsid=DTXSID8021931; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1140; RecordID=ARPathway2016_565; DatasetName=ARPathway2016; DTXSID=DTXSID8021931; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
NTP ICE eye irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 64.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2316; Record_ID=eye_irritation_158; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=64.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE eye irritation | EPA Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2311; Record_ID=eye_irritation_65; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE eye irritation | Intensity | 0.33 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2317; Record_ID=eye_irritation_1296; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Vitrigel; Endpoint=Intensity; Response=0.33; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE eye irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2314; Record_ID=eye_irritation_1296; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE eye irritation | Plateau level | 59 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2319; Record_ID=eye_irritation_1296; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Vitrigel; Endpoint=Plateau level; Response=59; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
NTP ICE skin irritation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Positive reaction | 16.9 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=1531; Record_ID=skin_irritation_invivo_19; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=16.90; Response_Unit=%; Species=Human; Reference=Robinson et al. 2001; 11422260; 10.1034/j.1600-0536.2001.045001001.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE skin irritation | Positive reaction | 28.6 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=1533; Record_ID=skin_irritation_invivo_21; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=28.6; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE skin irritation | TER | 2.3 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=5139; Record_ID=skin_irritation_invitro_2568; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=TER Corrosion; Endpoint=TER; Response=2.3; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE skin irritation | TER | 3.6 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=5140; Record_ID=skin_irritation_invitro_2567; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=TER Corrosion; Endpoint=TER; Response=3.6; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3623; Record_ID=skin_sensitization_invivo_903; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90180-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE skin sensitization | Induction dose per skin area | 648 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3621; Record_ID=skin_sensitization_invivo_903; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90180-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3627; Record_ID=skin_sensitization_invivo_903; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021931; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90180-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021931 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =50148.5 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15516045:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b66951ab8bb4dce1e7c756f140a4aba |
ECHA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | >1500 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/3/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15798641:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_347c96a7c3b1a9abde285abee6e6541c |
| ECHA | LEL | =3000 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/3/2?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15808705:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46ea067fb0e6be9b4604f954ac8f8cc0 |
| ECHA | LOAEL | =1000 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf31e4b0a7c65d1ccf59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/6/2?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844258_15845069_15847104_15847127_15850868_15850963:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0573dedc653c9c7e3f393c854c470a1f |
| ECHA | NOAEC | =3500 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23de4b0a7c65d232251; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/9/3?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822408_15822584_15823093_15823171:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e65dbe55a09b2473bfae9ee05499f39 |
| ECHA | NOAEC | >=158000 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/6/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID:15827462:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_84d6025f8d2a7e87255fcd0f14c08265 |
| ECHA | NOAEL | =130 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/9/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822492_15824023_15824024:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1047840c5ec9cd65372efddd45e27bc9 |
| ECHA | NOAEL | =200 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb7ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/9/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822492_15824023_15824024:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ccd76a37a6ada6e6ceafe32a333d492 |
| ECHA | NOAEL | >370 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf31e4b0a7c65d1ccf59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/6/2?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844258_15845069_15847104_15847127_15850868_15850963:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_05905a58be4eb4648ee2945ad89e106a |
| ECHA | NOAEL | <435 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf31e4b0a7c65d1ccf59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/6/2?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844258_15845069_15847104_15847127_15850868_15850963:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3040eba096eb088913907130c41f1445 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb7ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/9/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824021_15824022:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36b53e8c58f0cb2251d7333921109e6c |
| ECHA | NOAEL | =1127 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c15c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2096/7/6/2?documentUUID=e731448f-4c87-4e5e-aa4f-90b6daeffd79; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850401_15850402_15850403_15850404:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_116bfa453dd8ce0d11f36e15ac392883 |
| ECHA | NOAEL | =1243 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1205; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/6/2?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847372_15847723_15847844_15848108:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1b74069fcae5ac3e83751e7c54e13908 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =210 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632533_15632534:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5fdd311e04731fa44fc642d4cb06acc9 |
| ToxValDB GESTIS DNEL | DNEL systemic | =99 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632533_15632534:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c046970fa90c8ebbac6c8d4f293e6d7c |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =1 | % diet | Dog | oral | subchronic; 13 weeks | subchronic | LONG_REF=Final Report On Thirteen-Week Subacute Feeding In Beagle Dogs of ALFOL 6, Scientific Associates for Continental Oil Company, June 14, 1966.Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=62786; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639259_15639342:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e326d73e2be11251cbc4e3d91e5835b1 |
| ToxValDB HPVIS | NOAEL | >0.5 | % diet | Dog | oral | subchronic; 13 weeks | subchronic | LONG_REF=Final Report On Thirteen-Week Subacute Feeding In Beagle Dogs of ALFOL 6, Scientific Associates for Continental Oil Company, June 14, 1966.Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=61996; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639259_15639342:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3000b31a013aa61427ae0008081f0156 |
| ToxValDB HPVIS | NOAEL | >3500 | mg/m3 | Rat | inhalation | - | developmental | LONG_REF=B.K. Nelson, W.W. Brightwell, A. Khan, E.F. Krieg, Jr., A.M. Hoberman,"Developmental toxicology evaluation of 1-pentanol, 1-hexanol, and 2-ethyl-1-hexanol administered by inhalation to rats." (1989) Journal of the American College of Toxicology 8(2): 405-410. NIOSH, Division of Biomedical and Behavioral SciencesPosting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; QUALITY=2; EXTERNAL_SOURCE_ID=58225; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS:15642386:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46407d69c70af3db278419b2c23a0edd |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6CP2QER8GS | UNII | - | - | - | chemical | - |