NOAEL Studies
Cosmetic Ingredient
Hexyl Salicylate NOAEL Studies
INCI: HEXYL SALICYLATE
CAS: 6259-76-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =5 | mg/kg bw/day | Rat | oral: unspecified | 91 days | subchronic | EFSA FEEDAP - 2012 - OutputID 607 - body weight - systemic - Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2785 |
| EFSA | NOAEL | =5 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2785.; TITLE=Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2785; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614581:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ab5147820e47f46d6f593e5a882078d |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 191.4 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1797; Record_ID=adme_parameters_1181; Data_Type=Measured; DTXSID=DTXSID4038924; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=191.4; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE adme parameters | Fu | 0 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1796; Record_ID=adme_parameters_1181; Data_Type=Measured; DTXSID=DTXSID4038924; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 57.7292004099647 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10390; RecordID=ERPathway2016_356; DatasetName=ERPathway2016; DTXSID=DTXSID4038924; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=57.7292004099647; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE endocrine | ACC | 47.5953167173507 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10391; RecordID=ERPathway2016_356; DatasetName=ERPathway2016; DTXSID=DTXSID4038924; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=47.5953167173507; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10386; RecordID=ARPathway2016_1414; DatasetName=ARPathway2016; DTXSID=DTXSID4038924; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE endocrine | Model Score | 0.0173 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=10392; RecordID=ERPathway2016_356; DatasetName=ERPathway2016; DTXSID=DTXSID4038924; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0173; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
NTP ICE skin irritation 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Positive reaction | 0 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=984; Record_ID=skin_irritation_invivo_22; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 80.7 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=3339; Record_ID=skin_irritation_invitro_1053; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=EpiDerm Irritation; Endpoint=Viability; Response=80.7; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 88.4 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3342; Record_ID=skin_irritation_invitro_1077; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=88.4; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 94.56 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=3338; Record_ID=skin_irritation_invitro_1054; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=EpiSkin Irritation; Endpoint=Viability; Response=94.56; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 96.6 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3337; Record_ID=skin_irritation_invitro_1056; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=96.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 96.66 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=3336; Record_ID=skin_irritation_invitro_1058; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=EpiDerm Irritation; Endpoint=Viability; Response=96.66; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 98.6 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3326; Record_ID=skin_irritation_invitro_1059; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=98.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 99.85 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=3325; Record_ID=skin_irritation_invitro_1061; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=EpiSkin Irritation; Endpoint=Viability; Response=99.85; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 100.49 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=3318; Record_ID=skin_irritation_invitro_1063; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=EpiSkin Irritation; Endpoint=Viability; Response=100.49; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 102.17 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=3317; Record_ID=skin_irritation_invitro_1065; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=EpiDerm Irritation; Endpoint=Viability; Response=102.17; Response_Unit=%; Reference=Spielmann et al. 2007; 18186667; 10.1177/026119290703500614; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 103.6 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3316; Record_ID=skin_irritation_invitro_1067; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=103.6; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 104.1 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3315; Record_ID=skin_irritation_invitro_1069; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=104.1; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 105.1 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3314; Record_ID=skin_irritation_invitro_1071; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=105.1; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 108.1 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3313; Record_ID=skin_irritation_invitro_1073; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=108.1; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 112.2 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3341; Record_ID=skin_irritation_invitro_1079; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=112.2; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 113 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3343; Record_ID=skin_irritation_invitro_1075; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=113; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin irritation | Viability | 119.5 | % | - | Dermal | - | In Vitro; LabCyte EPI-MODEL24 Irritation | sheet=Data_invitro; excel_row=3340; Record_ID=skin_irritation_invitro_1081; Data_Type=In Vitro; Formulation_Name=hexyl salicylate; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=119.5; Response_Unit=%; Reference=Katoh and Hata 2011; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
NTP ICE skin sensitization 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 52.73 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1733; Record_ID=skin_sensitization_invitro_446; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=52.73; Reported_Response_Unit=ug/mL; Response=52.73; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | CD86, EC150 | 27.29 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8629; Record_ID=skin_sensitization_invitro_2385; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=27.29; Reported_Response_Unit=ug/mL; Response=27.29; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | CV75 | 147.7 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1718; Record_ID=skin_sensitization_invitro_446; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=h-CLAT; Endpoint=CV75; Reported_Response=147.7; Reported_Response_Unit=ug/mL; Response=147.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Depletion Cys | 3.9 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=145; Record_ID=skin_sensitization_invitro_54; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.9; Reported_Response_Unit=%; Response=3.9; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Depletion Lys | 1.1 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=164; Record_ID=skin_sensitization_invitro_54; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.1; Reported_Response_Unit=%; Response=1.1; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6267; Record_ID=skin_sensitization_invitro_1481; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | EC1.5 | 4000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6269; Record_ID=skin_sensitization_invitro_1482; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | EC3 | 0.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13324; Record_ID=skin_sensitization_invivo_3433; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=LLNA; Endpoint=EC3; Response=0.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | IC50 | 53.7 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6273; Record_ID=skin_sensitization_invitro_1482; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=53.69715902; Reported_Response_Unit=uM; Response=53.7; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | IC50 | 67.4 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6275; Record_ID=skin_sensitization_invitro_1481; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=67.400000000000006; Reported_Response_Unit=uM; Response=67.4; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Imax | 1.37 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6277; Record_ID=skin_sensitization_invitro_1482; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.369557416; Reported_Response_Unit=Unitless; Response=1.37; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Imax | 1.5 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6279; Record_ID=skin_sensitization_invitro_1481; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.5; Reported_Response_Unit=Unitless; Response=1.5; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9164; Record_ID=skin_sensitization_invivo_2027; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90230-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Induction dose per skin area | 2025 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9161; Record_ID=skin_sensitization_invivo_2027; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2025; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90230-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Induction dose per skin area | 35430 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9171; Record_ID=skin_sensitization_invivo_2028; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=30.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=35430; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066|Lapczynski et al. 2007; 18022307; 10.1016/j.fct.2007.09.045|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9170; Record_ID=skin_sensitization_invivo_2027; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4038924; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90230-8|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4038924 |
SCCS Opinion 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.1 | % | human | oral | developmental | reproductive toxicity | p.37 |
| SCCS Opinion | NOAEL | =3 | - | - | - | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =13 | - | - | - | 3 years | NOAEL study | p.46 |
| SCCS Opinion | NOAEL | =13.4 | % | - | dermal | 3 years | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =15 | - | - | oral | - | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =29 | mg/kg/day | rat | - | developmental | reproductive toxicity | p.45 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/day | human | oral | developmental | developmental toxicity | p.37 |
| SCCS Opinion | NOAEL | =75 | mg/kg/day | rat | - | developmental | reproductive toxicity | p.49 |
| SCCS Opinion | NOAEL | =75 | - | - | - | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =180 | mg/kg bw/day | rat | - | - | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =370 | mg/kg bw/day | rat | oral | 13-week | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =540 | mg/kg bw/day | rat | - | - | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =736 | - | - | - | 3 years | NOAEL study | p.46 |
| SCCS Opinion | NOAEL | =801 | - | - | - | 3 years | NOAEL study | p.46 |
| SCCS Opinion | NOAEL | =822 | - | - | - | 3 years | NOAEL study | p.46 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | 13-week | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | sub-chronic | repeated dose toxicity | p.38 |
| SCCS Opinion | NOAEL | =1127 | mg/kg | rat | oral | sub-acute | repeated dose toxicity | p.35 |
| SCCS Opinion | NOAEL | =1668 | - | - | - | 3 years | NOAEL study | p.46 |
| SCCS Opinion | NOAEL | =35433 | μg/cm2 | human | - | 2 weeks | sensitisation | p.32 |
| SCCS Opinion | NOAEL | =75000 | - | - | - | 3 years | NOAEL study | p.46 |
ECHA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =360 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be527; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14766/7/9/3?documentUUID=4af4dd5e-02c7-473f-bf7e-03a480be8b21; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15821877:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6675801f54a514a3e3eab72a4c83652b |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =1.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632551:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca10a1c526a3243384907a5b212f70db |
Regulatory source 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 3 | - | - | - | - | - | p.17 |
| Regulatory source | - | 13 | - | - | - | 3 years | - | p.46 |
| Regulatory source | - | 13.4 | % | - | dermal | 3 years | - | p.17 |
| Regulatory source | - | 15 | - | - | oral | - | - | p.45 |
| Regulatory source | - | 75 | - | - | - | - | - | p.17 |
| Regulatory source | - | 180 | mg/kg bw/day | rat | - | - | - | p.36 |
| Regulatory source | - | 370 | mg/kg bw/day | rat | oral | 13-week | - | p.35 |
| Regulatory source | - | 540 | mg/kg bw/day | rat | - | - | - | p.36 |
| Regulatory source | - | 736 | - | - | - | 3 years | - | p.46 |
| Regulatory source | - | 801 | - | - | - | 3 years | - | p.46 |
| Regulatory source | - | 822 | - | - | - | 3 years | - | p.46 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 13-week | - | p.35 |
| Regulatory source | - | 1668 | - | - | - | 3 years | - | p.46 |
| Regulatory source | - | =75000 | - | - | - | 3 years | - | p.46 |
| Regulatory source | developmental toxicity | 0.1 | % | human | oral | developmental | developmental toxicity | p.48 |
| Regulatory source | developmental toxicity | 75 | mg/kg bw/day | human | oral | developmental | developmental toxicity | p.37 |
| Regulatory source | developmental toxicity | 180 | mg/kg bw/day | rat | - | - | developmental toxicity | p.36 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/day | rat | oral | sub-chronic | repeated dose toxicity | p.38 |
| Regulatory source | repeated dose toxicity | 1127 | mg/kg | rat | oral | sub-acute | repeated dose toxicity | p.35 |
| Regulatory source | reproductive toxicity | 0.1 | % | human | oral | developmental | reproductive toxicity | p.37 |
| Regulatory source | reproductive toxicity | 29 | mg/kg/day | rat | - | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 75 | mg/kg/day | rat | - | developmental | reproductive toxicity | p.49 |
| Regulatory source | sensitisation | 35433 | μg/cm2 | human | - | 2 weeks | sensitisation | p.32 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8F78EY72YL | UNII | - | - | - | chemical | - |