Moderate Cosmetic Ingredient

Hirudinea Extract

INCI: HIRUDINEA EXTRACT

CAS Number
Not specifically assigned (hirudin peptide reference: 113274-56-9)
Function
Skin conditioning, anti-inflammatory
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction; however, anticoagulant activity may attract FDA drug-claim scrutiny

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Animal-origin protein with BSE/TSE risk assessment requirements; batch-to-batch variability in hirudin content; anticoagulant bioactivity may constitute a drug claim in some jurisdictions; allergenicity testing recommended; not COSMOS/ECOCERT-eligible as animal extract

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen

Frequently Asked Questions

Is Hirudinea Extract safe in cosmetics?

Animal-origin protein with BSE/TSE risk assessment requirements; batch-to-batch variability in hirudin content; anticoagulant bioactivity may constitute a drug claim in some jurisdictions; allergenicity testing recommended; not COSMOS/ECOCERT-eligible as animal extract The EU classifies Hirudinea Extract as "permitted". Safety rating: MODERATE.

Is Hirudinea Extract allowed in the EU?

Hirudinea Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hirudinea Extract do in cosmetics?

Hirudinea Extract functions as: Skin conditioning, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned (hirudin peptide reference: 113274-56-9).

What is the Margin of Safety for Hirudinea Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Hirudinea Extract compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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