NOAEL Studies
Active Ingredient
Homosalate NOAEL Studies
INCI: HOMOSALATE
CAS: 118-56-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 590 | mg/kg bw/day | rabbit | - | - | sub-chronic toxicity: dermal | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=67b5926a-9bbe-4828-b3d2-17e8f313465f_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=67b5926a-9bbe-4828-b3d2-17e8f313465f/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=4bb53fa2-1598-4e63-8203-4e6c3fa25c1f |
| ECHA | LOAEL | 1015 | mg/kg bw/day | rabbit | - | - | sub-chronic toxicity: dermal | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=67b5926a-9bbe-4828-b3d2-17e8f313465f_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=67b5926a-9bbe-4828-b3d2-17e8f313465f/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=d1e52a62-b6df-4393-b6d6-3a547ef70000 |
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=7cdf1407-8da8-4905-8e9b-381f973380d3_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=7cdf1407-8da8-4905-8e9b-381f973380d3/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=45a87dc1-1459-4337-8158-946d3fbb9d40 |
| ECHA | NOAEL | 860 | mg/kg bw/day | rat | oral: feed | - | carcinogenicity: oral | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=7cdf1407-8da8-4905-8e9b-381f973380d3_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=7cdf1407-8da8-4905-8e9b-381f973380d3/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=c8daa7e6-752b-4e52-8977-9b67455318b4 |
| ECHA | NOAEL | 50 | mg/kg bw/day | dog | oral: capsule | - | chronic toxicity: oral | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=3ffe527d-e73e-4791-b54f-5847532dc0ae_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=3ffe527d-e73e-4791-b54f-5847532dc0ae/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=45b999a4-1b10-4946-8d23-9aba949607c5 |
| ECHA | NOAEL | 86 | mg/kg bw/day | dog | oral: capsule | - | chronic toxicity: oral | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=3ffe527d-e73e-4791-b54f-5847532dc0ae_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=3ffe527d-e73e-4791-b54f-5847532dc0ae/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=0c5a682e-0b7e-490b-b6f3-de8fbef30eec |
| ECHA | NOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=a8c95254-3d28-4468-b96a-0ac41713a238_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=a8c95254-3d28-4468-b96a-0ac41713a238/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-04-19; basis=other:; key_result=false; entry_uuid=239c10a0-8248-474a-b979-ce2ca43fc1c6 |
| ECHA | NOAEL | <=120 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=a8c95254-3d28-4468-b96a-0ac41713a238_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=a8c95254-3d28-4468-b96a-0ac41713a238/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-04-19; basis=reduction in number of live offspring; key_result=false; upper_value=120; entry_uuid=764db93b-9ec2-4a49-bb51-8fd6f0ab686f |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | subcutaneous | - | toxicity to reproduction: other studies | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=e5705d48-73aa-432c-a4ca-a4036de5a1cb_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=e5705d48-73aa-432c-a4ca-a4036de5a1cb/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=e8373748-ef24-4e59-a25e-fbe38d15ab44 |
| ECHA | NOAEL | 1180 | mg/kg bw/day | rabbit | - | - | sub-chronic toxicity: dermal | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=67b5926a-9bbe-4828-b3d2-17e8f313465f_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=67b5926a-9bbe-4828-b3d2-17e8f313465f/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=c07d8c67-064d-468c-83bd-303e26d9301e |
| ECHA | NOAEL | 250 | mg/kg bw/day | dog | oral: capsule | - | sub-chronic toxicity: oral | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=8cccc97d-c2ed-4fb5-930f-b2a71925da09_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=8cccc97d-c2ed-4fb5-930f-b2a71925da09/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=6bb65e8d-58c9-4714-bcdd-d5406543e51d |
| ECHA | NOAEL | 430 | mg/kg bw/day | dog | oral: capsule | - | sub-chronic toxicity: oral | dossier=809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6z; document=8cccc97d-c2ed-4fb5-930f-b2a71925da09_809f0480-e0d7-4a09-aa08-99f1ccd93d78.i6d; document_key=8cccc97d-c2ed-4fb5-930f-b2a71925da09/809f0480-e0d7-4a09-aa08-99f1ccd93d78; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1963; basis=other:; key_result=false; entry_uuid=82467a19-1600-4bb6-b02a-bf6d7e16908e |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1514; row=2759; data_type=In Vivo; mixture=Chemical; chemical_name=3,3,5-Trimethylcyclohexyl salicylate; preferred_name=3,3,5-Trimethylcyclohexyl salicylate; dtxsid=DTXSID1026241; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1026241; source_file=acute_oral.xlsx |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 31.3030061241923 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2892; RecordID=ERPathway2016_332; DatasetName=ERPathway2016; DTXSID=DTXSID1026241; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=31.3030061241923; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1026241 |
| NTP ICE endocrine | ACC | 15.3394006763907 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2893; RecordID=ERPathway2016_332; DatasetName=ERPathway2016; DTXSID=DTXSID1026241; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=15.3394006763907; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1026241 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2888; RecordID=ARPathway2016_647; DatasetName=ARPathway2016; DTXSID=DTXSID1026241; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1026241 |
| NTP ICE endocrine | Model Score | 0.0217 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=2894; RecordID=ERPathway2016_332; DatasetName=ERPathway2016; DTXSID=DTXSID1026241; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0217; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1026241 |
NTP ICE skin sensitization 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4082; Record_ID=skin_sensitization_invivo_993; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1026241; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1026241 |
| NTP ICE skin sensitization | Relative reliability score | 4 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4086; Record_ID=skin_sensitization_invivo_993; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1026241; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022746; 10.1016/j.fct.2007.09.066; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1026241; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1026241 |
SCCS Opinion 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.5 | % | - | oral | - | NOAEL study | p.48 |
| SCCS Opinion | NOAEL | =2 | % | human | oral | 2 week | dermal absorption | p.38 |
| SCCS Opinion | NOAEL | =9 | - | - | - | - | NOAEL study | p.48 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | - | oral | Developmental | repeated dose toxicity | p.47 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/d | rat | oral | - | dermal absorption | p.48 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw/d | rat | oral | - | dermal absorption | p.48 |
| SCCS Opinion | NOAEL | =43 | mg/kg/day | rat | oral | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =50 | % | - | oral | Developmental | repeated dose toxicity | p.47 |
| SCCS Opinion | NOAEL | =50 | % | human | oral | developmental | repeated dose toxicity | Ref.: SCCS/1622/20 3, p.10 |
| SCCS Opinion | NOAEL | =75 | mg/kg | rat | oral | - | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/d | human | - | - | NOAEL study | p.47 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw | rat | oral | 14 days | repeated dose toxicity | p.20 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw | rat | - | 14 days | NOAEL study | p.27 |
| SCCS Opinion | NOAEL | =120 | mg/kg bw/d | rat | oral | - | NOAEL study | (Ref. 50), p.20 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | - | - | - | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =300 | mg/kg/day | - | - | - | reproductive toxicity | p.31 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | rat | oral | Developmental | repeated dose toxicity | p.9 |
| SCCS Opinion | NOAEL | >2000 | mg/kg bw | rat | oral | 14-day | repeated dose toxicity | p.39 |
ToxValDB EPA TSCA 8e 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =750 | mg/kg bw/day | Rat | oral | subchronic (developmental) | reproduction developmental | GUIDELINE=OECD 422; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=FYI-1608-1744_08.23.2016_Combined.pdf; TOXICOLOGICAL_EFFECT=F1: decreased pup weight; STUDY_GROUP=EPA TSCA 8e_dup_-_15956815_15956823:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_715f2bd4e0a9bec272a78dd613c3afe2 |
| ToxValDB EPA TSCA 8e | LOAEL | =300 | mg/kg bw/day | Rat | oral | subchronic (developmental) | reproduction developmental | GUIDELINE=OECD 422; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=FYI-1608-1744_08.23.2016_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: increased liver weights, changes in glucose concentrations and phosphorus concentrations; STUDY_GROUP=EPA TSCA 8e_dup_-_15956817_15956819_15956822:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5dd821d45a2336ec0544af7103d22d7e |
| ToxValDB EPA TSCA 8e | NOAEL | =120 | mg/kg bw/day | Rat | oral | subchronic (developmental) | reproduction developmental | GUIDELINE=OPPTS 870.3650 (OECD 422) - Combined Repeated Dose Toxicity with the Reproduction/Development Toxicity Screening Test; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=FYI-1608-1744_08.23.2016_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: no reproductive toxicity; STUDY_GROUP=EPA TSCA 8e_dup_-_15956815_15956823:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c281e205087413b63c003d6d26267748 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =16.09 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632565:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d58c633cbfe8a38f3cf908f1e93d18be |
Regulatory source 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.5 | % | - | oral | - | - | p.48 |
| Regulatory source | - | 9 | - | - | - | - | - | p.48 |
| Regulatory source | - | 10 | mg/kg bw/day | - | oral | - | - | p.10 |
| Regulatory source | - | 43 | mg/kg/day | rat | oral | - | - | p.41 |
| Regulatory source | - | 75 | mg/kg | rat | oral | - | - | p.41 |
| Regulatory source | - | 75 | mg/kg bw/d | human | - | - | - | p.47 |
| Regulatory source | - | 100 | mg/kg bw | rat | - | 14 days | - | p.27 |
| Regulatory source | - | 120 | mg/kg bw/d | rat | oral | - | - | p.20 |
| Regulatory source | - | 300 | mg/kg bw/day | - | - | - | - | p.30 |
| Regulatory source | dermal absorption | 2 | % | human | oral | 2 week | dermal absorption | p.38 |
| Regulatory source | dermal absorption | =10 | mg/kg bw/d | rat | oral | - | dermal absorption | p.48 |
| Regulatory source | dermal absorption | 20 | mg/kg bw/d | rat | oral | - | dermal absorption | p.48 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | - | oral | Developmental | developmental toxicity | p.31 |
| Regulatory source | genotoxicity | 100 | mg/kg bw | rat | oral | 14-day | genotoxicity | p.21 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg bw/day | - | oral | Developmental | repeated dose toxicity | p.47 |
| Regulatory source | repeated dose toxicity | 50 | % | - | oral | Developmental | repeated dose toxicity | p.47 |
| Regulatory source | repeated dose toxicity | 50 | % | human | oral | developmental | repeated dose toxicity | p.10 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw | rat | oral | 14 days | repeated dose toxicity | p.20 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw | rat | oral | 90-day | repeated dose toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw/d | rat | oral | subacute | repeated dose toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw/day | - | oral | - | repeated dose toxicity | p.50 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw/day | rat | oral | Developmental | repeated dose toxicity | p.9 |
| Regulatory source | repeated dose toxicity | 300 | mg/kg bw/day | human | - | developmental | repeated dose toxicity | p.9 |
| Regulatory source | repeated dose toxicity | >2000 | mg/kg bw | rat | oral | 14-day | repeated dose toxicity | p.39 |
| Regulatory source | reproductive toxicity | 300 | mg/kg/day | - | - | - | reproductive toxicity | p.31 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | V06SV4M95S | UNII | - | - | - | chemical | - |