Is Honokiol safe in cosmetics?
Honokiol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Honokiol
Also known as: 3',5-Diallyl-2,4'-biphenyldiol, 2-[4-Hydroxy-3-(2-propenyl)phenyl]-4-(2-propenyl)phenol, NSC 293100, UNII-11513CCO0N
INCI: HONOKIOL
Honokiol (CAS 35354-74-6) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin lightening, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 35354-74-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Honokiol is classified GHS Danger (H302, H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, skin lightening, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
InChIKey
FVYXIJYOAGAUQK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted, not restricted; used in cosmetics and supplements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Honokiol.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "35354-74-6", "anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "20-100", "sebum_reduction_pct_clinical": "5-10", "optimal_ph_for_efficacy": "5.0-7.0", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi…
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
anti_pollution
{"cas_number": "35354-74-6", "ingredient_class": "AhR_antagonist", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no",…
antioxidant
{"cas_number": "35354-74-6", "antioxidant_class": "polyphenol", "chemical_subclass": "biphenolic neolignan", "molecular_weight_daltons": "266.34", "orac_value_umol_te_per_g": "13800", "dpph_radical_scavenging_ic50_ug_per_ml": "14-24", "abts_trolox_equivalent": "not available", "singlet_oxygen_quenching": "not available", "superoxide_dismutase_mimetic": "not available", "hydroxyl_radical_scavenging…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Honokiol.
Known Synonyms
3',5-Diallyl-2,4'-biphenyldiol
2-[4-Hydroxy-3-(2-propenyl)phenyl]-4-(2-propenyl)phenol
NSC 293100
UNII-11513CCO0N
Chemical Function
Antioxidant
Softener and conditioner
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HONOKIOL
ChEMBL ID
CHEMBL16901
Adverse Event Associations
29
Frequently Asked Questions
Is Honokiol allowed in the EU?
Honokiol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Honokiol do in cosmetics?
Honokiol functions as: Antioxidant, skin lightening, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 35354-74-6.
Is Honokiol used outside cosmetics?
Honokiol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Honokiol have different safety status in cosmetics vs industrial chemicals?
Honokiol is classified GHS Danger (H302, H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Honokiol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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