NOAEL Studies Cosmetic Ingredient

Hydrolyzed Silica NOAEL Studies

INCI: HYDROLYZED SILICA

CAS: 7631-86-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 730 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 180 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 800 mg/kg bw/day dog oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1340 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1350 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1600 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1996 IARC Monographs -
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >5.01 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1099; Record_ID=acute_inhalation_2961; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1029677; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.01; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/3/3/?documentUUID=4ce431bb-8e7c-46af-a818-2e5ab5479145; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=2066; Record_ID=cancer_3858; Data_Type=WOE; Formulation_Name=Silica; Mixture=Chemical; DTXSID=DTXSID1029677; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/86; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14308; RecordID=ARPathway2016_1537; DatasetName=ARPathway2016; DTXSID=DTXSID1029677; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
NTP ICE eye irritation 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 2.7 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=621; Record_ID=eye_irritation_167; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1029677; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=2.7; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
NTP ICE eye irritation Intensity 0.05 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=626; Record_ID=eye_irritation_1229; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1029677; Assay=Vitrigel; Endpoint=Intensity; Response=0.05; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
NTP ICE eye irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=625; Record_ID=eye_irritation_1229; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1029677; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
NTP ICE eye irritation Plateau level 0 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=624; Record_ID=eye_irritation_1229; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1029677; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1029677
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =4 - - - - NOAEL study p.59
SCCS Opinion NOAEL =5 % - oral 90 days NOAEL study p.32
SCCS Opinion NOAEL =6.7 % - oral subchronic repeated dose toxicity p.31
SCCS Opinion NOAEL =500 mg/kg - - 3-week NOAEL study p.33
SCCS Opinion NOAEL =500 mg/kg/day rat oral 4-week reproductive toxicity p.52
SCCS Opinion NOAEL =1340 mg/kg/day rat oral Developmental developmental toxicity p.52
SCCS Opinion NOAEL =1350 mg/kg/day rat oral developmental developmental toxicity p.52
ToxValDB Cal OEHHA REL derivations 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Cal OEHHA REL derivations BMCL (01) =2.12 (mg/m3 )-yr CDE Human inhalation chronic; 24 years occupational LONG_REF=Hnizdo E, Sluis-Cremer GK. 1993. Risk of silicosis in a cohort of white South African gold miners. Am J Ind Med. 24(4):447-57.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Silicosis; STUDY_GROUP=Cal OEHHA REL derivations:15952141:-:-white South African gold miners; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ec28a21819b56a6f69a54aaa9e59e96
ECHA 62 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEC =2.5 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827924_15827925_15827926_15828605_15828606_15828607:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3b025c7ffcb14e1232cd9f46a1030c9
ECHA LOAEC =10 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827865_15827866_15827867_15829312:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7d5f171d19c9526fc2db9e7c0ca62d9
ECHA LOAEC =50.4 mg/m3 Rat inhalation short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15828046:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e97a7b0fd537fe53f6f8e205588044a4
ECHA LOAEL ~5.41 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827790_15827791:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47306016c24d120c926b6837824027e9
ECHA LOAEL =25.1 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827817_15827818_15827819:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e67559a5f80cbdcb52c5b537fed97380
ECHA LOAEL =25.2 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827367_15827368_15827369:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3f039a1afac756dabff73165269c811
ECHA LOAEL ~25.43 mg/m3 Rat inhalation acute; 5 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15829228:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_189fb50f20dedc11fd3ac84c277fba23
ECHA LOAEL =50.4 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fc4e4b096bca877eb62; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15827022:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48aafa8c99a7b35e98a30b9f2ad61395
ECHA LOAEL =50.5 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828889_15828890:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04f7ecbd1f6860c19b6cd9bd9e43bd84
ECHA LOAEL <=80 mg/m3 Rat inhalation chronic; 1 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15829167:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13c0b6187b5b9de055bdc1906fa55962
ECHA LOAEL >=1350 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf054; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/9/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821996_15823468_15823664:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ba2a22ab2c1dbb4a930c3862a8528f5d
ECHA NOAEC =0.5 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827865_15827866_15827867_15829312:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dad0a761745a63857c1fa1f0e00ff1c8
ECHA NOAEC =1 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827924_15827925_15827926_15828605_15828606_15828607:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02e1f9fe214e255a18cd7a4acd2d3056
ECHA NOAEC >1.3 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827825_15828365_15829667_15829668:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3e3572cc694d85fe0ab7899b759dc77
ECHA NOAEC =2 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827865_15827866_15827867_15829312:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bffd72575273c4342a7cca757029baf3
ECHA NOAEC =2.05 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827865_15827866_15827867_15829312:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f3e4f56ff046b63a2cbeb6ab679349a
ECHA NOAEC =2.5 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829069_15829070_15829071:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2340c33ef220b476adf18af8f273927c
ECHA NOAEC =5 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827924_15827925_15827926_15828605_15828606_15828607:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f059da37dde95d9c9f0347c553db470
ECHA NOAEC <5.9 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827825_15828365_15829667_15829668:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c30474f3129377cb7ea7c9995e75ae3f
ECHA NOAEC >=10 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829069_15829070_15829071:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7e23ecd80586bf3fd8028fa8f0c6c20
ECHA NOAEC =10.1 mg/m3 Rat inhalation short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15828045:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fd6dce6afdbdb9246db5a9dd24832657
ECHA NOAEC <31 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827825_15828365_15829667_15829668:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42e2a6d18353bf9bf264f923531c4cf9
ECHA NOAEC <46 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827825_15828365_15829667_15829668:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf06625238b3afbc2a3c54bc763fc34f
ECHA NOAEC >=50 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829069_15829070_15829071:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3cbede2f5a99be80dca1a5ed3c6cad15
ECHA NOAEL <1 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827995_15827996_15827997:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_acd1ef76fe286b00ddf2806de86ebccb
ECHA NOAEL ~1.39 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827790_15827791:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_042919ebce73cd14801375baadc97cde
ECHA NOAEL ~4.97 mg/m3 Rat inhalation acute; 5 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15829227:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_423ad650afde5741216ae1aec92277e2
ECHA NOAEL =5 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827995_15827996_15827997:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02604666702e4a706e71d8e1fb807d01
ECHA NOAEL =5.13 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827817_15827818_15827819:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_022992f92281a4d1f4b2415c0a715394
ECHA NOAEL =5.39 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827367_15827368_15827369:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8696476f454ab8ff0d46ece5647be93b
ECHA NOAEL <17 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827256_15827288:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f2646ed777d8e16efff1ed5fd393da7
ECHA NOAEL <31 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827256_15827288:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a39a026c5cca02a95e1741af065c7dd8
ECHA NOAEL >=100 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b476b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820208:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2a0af45ce86ea351fbb1aed6a53de563
ECHA NOAEL >=491.5 mg/kg bw/day Rat oral chronic; 6 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cba86; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|gross pathology|haematology|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|hematology|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833882_15849853:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_693ac634a1dd1088a2a28df67e3b1f69
ECHA NOAEL >=492 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9dda; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/9/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15862146:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6420d46bd47195e8b31a226cc53d634b
ECHA NOAEL =497 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9de9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/9/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=F1: clinical signs|F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ECHA IUCLID:15859327:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e871ada24e0b1e9373a534c5ea340877
ECHA NOAEL >=500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf057; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/9/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15825161:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f22a4eccacad3aa4b4010713374039b2
ECHA NOAEL >=518 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9dda; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/9/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15862253:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bcb38c14f596d746a2e5b8ceeb249544
ECHA NOAEL =1000 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf04e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/9/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820777_15821321_15821392_15821732_15825165_15825166:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f655684d157a1b8e244a30bc9fa93fc1
ECHA NOAEL =1340 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d232086; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/26622?documentUUID=667256b2-8daa-4071-ac8d-e964ca257dca; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822532_15825159_15825160:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d08ef9886e6163ed8bd66ffd9f54106e
ECHA NOAEL =1350 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c2e4b0a7c65d230103; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/26622?documentUUID=667256b2-8daa-4071-ac8d-e964ca257dca; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822113_15822230_15822637_15822699_15822712_15823022_15825163_15825164:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dda70008933e89569dedd5cc5beb390d
ECHA NOAEL =1600 mg/kg bw/day Hamster oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f571; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/26622?documentUUID=667256b2-8daa-4071-ac8d-e964ca257dca; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15820807:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24365309d5c7c4ad94d3f60eedda2b81
ECHA NOAEL ~1800 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b476e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820017_15820210:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_017dd1ce8bbeb4462967a4b090802af7
ECHA NOAEL ~2000 mg/kg bw/day Rat oral chronic; 103 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cba45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15847979:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dce149276dc1fc2f1dc65e7b608cd93a
ECHA NOAEL =2250 ppm Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cba8a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15846710:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87df4b078b6cedbab2d0e7c012c9f889
ECHA NOAEL =2500 mg/kg bw/day Rat oral - repeat dose other QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cba50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|gross pathology|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|hematology; STUDY_GROUP=ECHA IUCLID:15849848:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_353390048adf3fc3fc7d8a396d7df4fc
ECHA NOAEL ~3000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b476e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820017_15820210:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f9c8ad80e60940e9297f2809df7ba718
ECHA NOAEL ~3200 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b476e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820018_15820209:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ca8db419ac2dfe39bf9f73906fe6d0b
ECHA NOAEL =3900 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b476e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15820211:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f321ffbee3046ba4c47caf6d8317f06a
ECHA NOAEL ~4000 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4771; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820046_15820214:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f9d66fb6a38723760c507cb66dd8a25
ECHA NOAEL ~5000 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4771; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820045_15820212:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e558cdb56ebd4972f4981de4d163791
ECHA NOAEL ~7000 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4771; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820045_15820212:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2bea1e06dcfbb632cb4ffaae563e39a
ECHA NOAEL =9250 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4771; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15820213:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e59eb581c4ece0747cdd09d76346e0f6
ECHA NOAEL >=10000 mg/kg bw/day Rabbit dermal short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d5de4b096bca87757f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/4?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826142_15826275:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b28ef1f877e870530be35c717c72690
ECHA NOAEL ~13000 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b4771; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/8?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820046_15820214:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5e0b6e05fe4038694924075b2229d3af
ECHA NOEL =0.94 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827817_15827818_15827819:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_904efa5e19678580caecaed92adfd0dd
ECHA NOEL =1.16 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827367_15827368_15827369:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f1bc509b4d60c5c62c3fceaef7528a3d
ECHA NOEL =10 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fc4e4b096bca877ebd8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/3?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15827049:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5867f355703f6033fe50f273ee70965
ECHA NOEL >=500 mg/kg bw/day Rat oral chronic; 6 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd6e4b0a7c65d227a9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833882_15849853:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b8ba2bf8670719e2e8fd3183b7b29c2
ECHA NOEL >=4800 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeeee4b0a7c65d1cba37; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID:15849846:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_94f2b6224d0bfffba9978bccceddf1af
ECHA NOEL =7950 mg/kg bw/day Rat oral chronic; 26 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cba7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15849851:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2b11ebdcd3612e71bae829edd8f9905d
ECHA NOEL =8980 mg/kg bw/day Rat oral chronic; 26 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeefe4b0a7c65d1cba7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15556/7/6/2?documentUUID=cea0d500-d9b2-49ad-8f19-1eac4f804f72; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15849852:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d9afc61c9a29e20cfb47748223c7dbf
ToxValDB ECOTOX 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =50 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Toxicology282(3): 82-87 Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice 2011; TITLE=TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice; AUTHOR=Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam; DOI=10.1016/j.tox.2011.01.013; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=154284; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Genetics: Cyp1A1 mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594583_15603676_15603677_15604650_15608467:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f657867638dec6e226b83362cfe56619
ToxValDB ECOTOX LOEL =500 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Toxicology282(3): 82-87 Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice 2011; TITLE=TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice; AUTHOR=Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam; DOI=10.1016/j.tox.2011.01.013; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=154284; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594583_15603676_15603677_15604650_15608467:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de81bf7a0a05ce65d197b93df4f772c0
ToxValDB ECOTOX LOEL =665 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Toxicology282(3): 82-87 Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice 2011; TITLE=TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice; AUTHOR=Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam; DOI=10.1016/j.tox.2011.01.013; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=154284; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594583_15603676_15603677_15604650_15608467:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e0a4258d8b60fc4198a2115f842df4c6
ToxValDB ECOTOX NOEL =1.66e-16 mM Mouse oral short-term; 25 days short-term LONG_REF=Eur. J. Pharmacol.135(3): 313-319 Davenas,E., B. Poitevin, and J. Benveniste Effect on Mouse Peritoneal Macrophages of Orally Administered Very High Dilutions of Silica 1987; TITLE=Effect on Mouse Peritoneal Macrophages of Orally Administered Very High Dilutions of Silica; AUTHOR=Davenas,E., B. Poitevin, and J. Benveniste; DOI=10.1016/0014-2999(87)90680-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101537; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Immunological: Macrophage activity; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608165_15608806:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=60037bc2e4b29edf8abf741066c4eefe
ToxValDB ECOTOX NOEL =1.66e-8 mM Mouse oral short-term; 25 days short-term LONG_REF=Eur. J. Pharmacol.135(3): 313-319 Davenas,E., B. Poitevin, and J. Benveniste Effect on Mouse Peritoneal Macrophages of Orally Administered Very High Dilutions of Silica 1987; TITLE=Effect on Mouse Peritoneal Macrophages of Orally Administered Very High Dilutions of Silica; AUTHOR=Davenas,E., B. Poitevin, and J. Benveniste; DOI=10.1016/0014-2999(87)90680-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101537; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Immunological: Macrophage activity; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608165_15608806:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9ac181aa80e07f7384d49a74de238460
ToxValDB ECOTOX NOEL =100 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Toxicology282(3): 82-87 Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice 2011; TITLE=TCDD Adsorbed on Silica as a Model for TCDD Contaminated Soils: Evidence for Suppression of Humoral Immunity in Mice; AUTHOR=Kaplan,B.L.F., R.B. Crawford, N. Kovalova, A. Arencibia, S.S. Kim, T.J. Pinnavaia, S.A. Boyd, B.J. Teppen, and N.E. Kam; DOI=10.1016/j.tox.2011.01.013; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=154284; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594583_15603676_15603677_15604650_15608467:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0912c8056ee5cb8ad6ae75abf1052cc8
ToxValDB RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfC =0.003 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15658924:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec9afab3a9860fac4d2528b203bcb832
ToxValDB TX TCEQ 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB TX TCEQ LOAEL =15 mg/m3 Monkey inhalation chronic; 18 months chronic LONG_REF=Groth DH, WJ Moorman, DW Lynch, LE Stettler, WD Wagner, RW Hornung. 1981. Chronic effects of inhaled amorphous silicas in animals. American Society for Testing and Materials Special Technical Publication 732, 118-143.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5acf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/silica_amorphous.pdf; YEAR=2011 Accessible 2013; ORIGINAL_YEAR=2011 Accessible 2013; TOXICOLOGICAL_EFFECT=Pulmonary effects such as chronic inflammation, respiratory impairment, and decrese in pulmonary function.; STUDY_GROUP=TX TCEQ_dup_-_15954646_15954647_15954648:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a08be49dd714b42674a829893258e58d
ToxValDB TX TCEQ LOAEL (ADJ) =2.679 mg/m3 Monkey inhalation chronic; 18 months chronic LONG_REF=Groth DH, WJ Moorman, DW Lynch, LE Stettler, WD Wagner, RW Hornung. 1981. Chronic effects of inhaled amorphous silicas in animals. American Society for Testing and Materials Special Technical Publication 732, 118-143.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5acf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/silica_amorphous.pdf; YEAR=2011 Accessible 2013; ORIGINAL_YEAR=2011 Accessible 2013; TOXICOLOGICAL_EFFECT=Pulmonary effects such as chronic inflammation, respiratory impairment, and decrese in pulmonary function.; STUDY_GROUP=TX TCEQ_dup_-_15954646_15954647_15954648:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e4de90a320f546513766e54eb539339
ToxValDB TX TCEQ LOAEL (HEC) =1.98 mg/m3 Monkey inhalation chronic; 18 months chronic LONG_REF=Groth DH, WJ Moorman, DW Lynch, LE Stettler, WD Wagner, RW Hornung. 1981. Chronic effects of inhaled amorphous silicas in animals. American Society for Testing and Materials Special Technical Publication 732, 118-143.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5acf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/silica_amorphous.pdf; YEAR=2011 Accessible 2013; ORIGINAL_YEAR=2011 Accessible 2013; TOXICOLOGICAL_EFFECT=Pulmonary effects such as chronic inflammation, respiratory impairment, and decrese in pulmonary function.; STUDY_GROUP=TX TCEQ_dup_-_15954646_15954647_15954648:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_16acbd40ab2b952caf5530118aa9b854
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 4 - - - - - p.59
Regulatory source - 5 % - oral 90 days - p.32
Regulatory source - 500 mg/kg - - 3-week - p.33
Regulatory source developmental toxicity 1340 mg/kg/day rat oral Developmental developmental toxicity p.52
Regulatory source developmental toxicity 1350 mg/kg/day rat oral developmental developmental toxicity p.52
Regulatory source repeated dose toxicity 6.7 % - oral subchronic repeated dose toxicity p.31
Regulatory source reproductive toxicity 500 mg/kg/day rat oral 4-week reproductive toxicity p.52
openFDA substances 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ETJ7Z6XBU4 UNII - - - chemical -
openFDA substances FDA UNII substance identifier concept identifier - - - concept -