Hydroxy Tetramethylpiperidine Oxide

INCI: HYDROXY TETRAMETHYLPIPERIDINE OXIDE

CAS Number
2226-96-2 (TEMPOL / 4-Hydroxy-TEMPO)
Function
Antioxidant (stable nitroxide free radical scavenger)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” CIR Expert Panel concluded safe in cosmetics in present practices of use and concentration (2025 final report)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Stable free radical antioxidant with adequate margin of safety; CIR Expert Panel concluded safe in cosmetics (2025 final report).

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Concern Level: Low

Frequently Asked Questions

Is Hydroxy Tetramethylpiperidine Oxide safe in cosmetics?

Stable free radical antioxidant with adequate margin of safety; CIR Expert Panel concluded safe in cosmetics (2025 final report). The EU classifies Hydroxy Tetramethylpiperidine Oxide as "permitted". Safety rating: GOOD.

Is Hydroxy Tetramethylpiperidine Oxide allowed in the EU?

Hydroxy Tetramethylpiperidine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxy Tetramethylpiperidine Oxide do in cosmetics?

Hydroxy Tetramethylpiperidine Oxide functions as: Antioxidant (stable nitroxide free radical scavenger). It is classified as a cosmetic ingredient in our database. CAS number: 2226-96-2 (TEMPOL / 4-Hydroxy-TEMPO).

What is the Margin of Safety for Hydroxy Tetramethylpiperidine Oxide?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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