Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Hydroxyacetophenone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 45 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.600 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ulations, and concluded that Hydroxyacetophenone is safe in cosmetics in the present practices of use and concentration described in this safety assessment. INTRODUCTION This assessment reviews the safety of Hydroxyacetophenone as used in cosmetic formulations. According to the web- base
ulations, and concluded that Hydroxyacetophenone is safe in cosmetics in the present practices of use and concentration described in this safety assessment. INTRODUCTION This assessment reviews the safety of Hydroxyacetophenone as used in cosmetic formulations. According to the web- base
ulations, and concluded that Hydroxyacetophenone is safe in cosmetics in the present practices of use and concentration described in this safety assessment. INTRODUCTION This assessment reviews the safety of Hydroxyacetophenone as used in cosmetic formulations. According to the web- base
ulations, and concluded that Hydroxyacetophenone is safe in cosmetics in the present practices of use and concentration described in this safety assessment. INTRODUCTION This assessment reviews the safety of Hydroxyacetophenone as used in cosmetic formulations. According to the web- base
ulations, and concluded that Hydroxyacetophenone is safe in cosmetics in the present practices of use and concentration described in this safety assessment. INTRODUCTION This assessment reviews the safety of Hydroxyacetophenone as used in cosmetic formulations. According to the web- base
Expert Verdict
Hydroxyacetophenone is a key component of scientifically validated preservative combinations that selectively inhibit pathogenic bacteria while preserving beneficial skin commensals, making it a strong candidate for microbiome-certified and sensitive skin formulations.
Regulatory Flags
Frequently Asked Questions
Is Hydroxyacetophenone safe in cosmetics?
Hydroxyacetophenone is a key component of scientifically validated preservative combinations that selectively inhibit pathogenic bacteria while preserving beneficial skin commensals, making it a strong candidate for microbiome-certified and sensitive skin formulations. The EU classifies Hydroxyacetophenone as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Hydroxyacetophenone allowed in the EU?
Hydroxyacetophenone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyacetophenone do in cosmetics?
Hydroxyacetophenone functions as: Preservative Booster, Antimicrobial, Skin Conditioning, Antioxidant. It is classified as a Preservative in our database. CAS number: 99-93-4.
What is the Margin of Safety for Hydroxyacetophenone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxyacetophenone?
The NOAEL (No Observed Adverse Effect Level) for Hydroxyacetophenone is 45 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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