Also known as: BRN 1703666, Caprylohydroxamic acid, EINECS 230-936-7, Octanoylhydroxamic acid, Taselin (+2 more)
INCI: CAPRYLHYDROXAMIC ACID
Caprylhydroxamic Acid (CAS 7377-03-9) is a cosmetic preservative functioning as preservative booster, chelating agent. Reported NOAEL =500 mg/kg bw/day in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: permitted; 4 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
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Margin of Safety, dermal absorption, and sensitization profile summaries for Caprylhydroxamic Acid.
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4 study endpoints found for Caprylhydroxamic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =500 mg/kg bw/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =500 mg/kg bw/day | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =500 mg/kg bw/day | oral | rat | developmental toxicity | CIR Safety Assessment |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ation-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics
ation-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics
ation-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics
ation-induction-level (WoE NESIL) of 1056 μg/cm2. The Panel concluded that Caprylhydroxamic Acid is safe in cosmetics in the present practices of use and concentration described in this safety assessment. Keywords Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Safety, Cosmetics
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_preservative | - | All cosmetics (leave-on/rinse-off) |
Preliminary editorial summary for Caprylhydroxamic Acid — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Caprylhydroxamic Acid by CAS number or substance name.
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the introduction volume of the chemical exceeds 1...
Caprylhydroxamic Acid has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Caprylhydroxamic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Caprylhydroxamic Acid functions as: preservative booster, chelating agent. It is classified as a Preservative in our database. CAS number: 7377-03-9.
The NOAEL (No Observed Adverse Effect Level) for Caprylhydroxamic Acid is =500 mg/kg bw/day based on a developmental toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: CIR Safety Assessment.
Caprylhydroxamic Acid also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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