Hydroxycinnamoyl Dipeptide-27 Amide

INCI: HYDROXYCINNAMOYL DIPEPTIDE-27 AMIDE

CAS Number
Not publicly assigned (proprietary peptide conjugate)
Function
Antioxidant, skin conditioning (hydroxycinnamic acid-peptide hybrid active)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no CFR restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Critical data gap: No CIR review, no SCCS opinion, extremely limited published toxicological literature. CPSR will require full supplier safety dossier (acute tox, irritation, sensitization, mutagenicity minimum). Novel bioactive โ€” regulatory scrutiny may be higher.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Hydroxycinnamoyl Dipeptide-27 Amide safe in cosmetics?

Critical data gap: No CIR review, no SCCS opinion, extremely limited published toxicological literature. CPSR will require full supplier safety dossier (acute tox, irritation, sensitization, mutagenicity minimum). Novel bioactive โ€” regulatory scrutiny may be higher. The EU classifies Hydroxycinnamoyl Dipeptide-27 Amide as "permitted". Safety rating: MODERATE.

Is Hydroxycinnamoyl Dipeptide-27 Amide allowed in the EU?

Hydroxycinnamoyl Dipeptide-27 Amide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxycinnamoyl Dipeptide-27 Amide do in cosmetics?

Hydroxycinnamoyl Dipeptide-27 Amide functions as: Antioxidant, skin conditioning (hydroxycinnamic acid-peptide hybrid active). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (proprietary peptide conjugate).

What is the Margin of Safety for Hydroxycinnamoyl Dipeptide-27 Amide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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