Regulatory Status
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Safety Data
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Expert Verdict
This is a pharmaceutical active ingredient, not a cosmetic ingredient. Inclusion in a cosmetic product would reclassify it as a medicinal product under EU and US law. Systemic absorption risk, skin atrophy with prolonged use, and HPA axis suppression are documented concerns. Not approvable in a CPSR.
Frequently Asked Questions
Is Hydroxycortisone Succinate safe in cosmetics?
This is a pharmaceutical active ingredient, not a cosmetic ingredient. Inclusion in a cosmetic product would reclassify it as a medicinal product under EU and US law. Systemic absorption risk, skin atrophy with prolonged use, and HPA axis suppression are documented concerns. Not approvable in a CPSR. The EU classifies Hydroxycortisone Succinate as "restricted". Safety rating: POOR.
Is Hydroxycortisone Succinate allowed in the EU?
Hydroxycortisone Succinate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxycortisone Succinate do in cosmetics?
Hydroxycortisone Succinate functions as: Anti-inflammatory (pharmaceutical active — corticosteroid). It is classified as a cosmetic ingredient in our database. CAS number: 2203-97-6 (free acid); 125-04-2 (sodium salt); 83784-20-7 (hydrate).
What is the Margin of Safety for Hydroxycortisone Succinate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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