NOAEL Studies Cosmetic Ingredient

Hydroxydichlorodiphenyl Ether (Diclosan) NOAEL Studies

INCI: HYDROXYDICHLORODIPHENYL ETHER

CAS: 3380-30-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =750 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c797c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834515_15834516_15834517:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2bc4677c66d4b8552c84971f65faa86c
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7988; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843963_15843964:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f6bf01f7463a35e4c5f3584bd5c52ee
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat dermal short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e7ce4b096bca8779e17; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826529_15826530_15826531:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f21ece543e601b8ef9312d6440740d1
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c797c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834515_15834516_15834517:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2e0a0960214c04d257ab3efc1169d52b
ToxValDB_ECHA_IUCLID NOAEL =20 mg/kg bw/day Rat oral chronic; 92 days chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7988; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843963_15843964:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18a2b93703776bf175410dfaab8b151c
ToxValDB_ECHA_IUCLID NOEL =10 mg/kg bw/day Rat dermal short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e7ce4b096bca8779e17; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826529_15826530_15826531:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56ba323c7bef40761e7aa35ab7c7a176
ToxValDB_ECHA_IUCLID NOEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c797c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/4317?documentUUID=483ad8ee-1fe8-4fd9-b313-ed37e4e6aa78; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834515_15834516_15834517:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_abf6677195af3aafddb3ab7165c209f4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 814H7B74XK UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H8Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"814H7B74XK"}
openFDA substances FDA UNII substance identifier 814H7B74XK UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H8Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"814H7B74XK"}
openFDA substances FDA UNII substance identifier 814H7B74XK UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H8Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"814H7B74XK"}
openFDA substances FDA UNII substance identifier 814H7B74XK UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H8Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"814H7B74XK"}