Also known as: Snoclosan, UNII-814H7B74XK
INCI: HYDROXYDICHLORODIPHENYL ETHER
Hydroxydichlorodiphenyl Ether (Diclosan) (CAS 3380-30-1) is a cosmetic cosmetic ingredient functioning as Antimicrobial / preservative. Reported NOAEL =20 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted, max 0.3%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 3380-30-1 →
Hydroxydichlorodiphenyl Ether (Diclosan) is classified GHS Danger (H318, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.3%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxydichlorodiphenyl Ether (Diclosan).
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for Hydroxydichlorodiphenyl Ether (Diclosan). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =20 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | dermal | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: ATP10
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Hydroxydichlorodiphenyl Ether (Diclosan).
Public NOAEL study rows linked to Hydroxydichlorodiphenyl Ether (Diclosan) by CAS number or substance name.
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Hydroxydichlorodiphenyl Ether (Diclosan) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted. 3 toxicological study endpoint(s) are available in our database.
Hydroxydichlorodiphenyl Ether (Diclosan) EU regulatory status: restricted. Maximum allowed concentration: 0.3%. This is based on EU Regulation 1223/2009 and its amendments.
Hydroxydichlorodiphenyl Ether (Diclosan) functions as: Antimicrobial / preservative. It is classified as a cosmetic ingredient in our database. CAS number: 3380-30-1.
The NOAEL (No Observed Adverse Effect Level) for Hydroxydichlorodiphenyl Ether (Diclosan) is =20 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Hydroxydichlorodiphenyl Ether (Diclosan) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Hydroxydichlorodiphenyl Ether (Diclosan) is classified GHS Danger (H318, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.3%.
Check Hydroxydichlorodiphenyl Ether (Diclosan) compliance across multiple jurisdictions:
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