NOAEL Studies Cosmetic Ingredient

Hydroxyethoxy Aminopyrazolopyridine HCl NOAEL Studies

INCI: HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL

CAS: 1079221-49-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1.67 mg/kg bw/d human oral prenatal developmental toxicity p.24
SCCS Opinion NOAEL =3.33 mg/kg bw/d human oral prenatal developmental toxicity p.24
SCCS Opinion NOAEL =10 mg/kg bw/day - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =10 mg/kg/day - - developmental developmental toxicity p.23
SCCS Opinion NOAEL =30 mg/kg bw/day rat oral 90-day developmental toxicity p.25
SCCS Opinion NOAEL =100 mg/kg bw/day rat - - NOAEL study p.17
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =30 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e1d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/5635?documentUUID=f8f19aa2-0938-4cfc-b1b4-f291d972f227; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15841896:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f1a298213527a681bc0011059e98e8de
Regulatory source 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/day rat - - - p.17
Regulatory source dermal absorption 10 mg/kg bw/day human dermal - dermal absorption p.24
Regulatory source developmental toxicity =1.67 mg/kg bw/d human oral prenatal developmental toxicity p.24
Regulatory source developmental toxicity =3.33 mg/kg bw/d human oral prenatal developmental toxicity p.24
Regulatory source developmental toxicity 10 mg/kg/day - - developmental developmental toxicity p.23
Regulatory source developmental toxicity 10 mg/kg bw/day rat oral 90-day developmental toxicity p.25
Regulatory source developmental toxicity 30 mg/kg bw/day rat oral 90-day developmental toxicity p.25
Regulatory source genotoxicity 10 mg/kg bw/day - - Chronic genotoxicity p.18