Also known as: Ethanol, 2-[(3-aminopyrazolo[1,5-a]pyridin-2-yl)oxy]-, hydrochloride (1:1), 2-((3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy)ethanol hydrochloride (1:1), 2-(2-Hydroxyethoxy)-3-aminopyrazolo[1,5-a]pyridine hydrochloride, 2-[(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxy]ethan-1-ol hydrochloride, EC No.: 695-745-7 (+3 more)
INCI: HYDROXYETHOXY AMINOPYRAZOLOPYRIDINE HCL
Hydroxyethoxy Aminopyrazolopyridine HCl (CAS 1079221-49-0) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative hair dye substance, code A161). NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 2.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1079221-49-0 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyethoxy Aminopyrazolopyridine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Hydroxyethoxy Aminopyrazolopyridine HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1.67 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =1.67 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =1.67 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =1.67 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =3.33 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =3.33 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =3.33 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =3.33 mg/kg bw/d | oral | human | developmental toxicity | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw/day | - | - | genotoxicity | SCCS_vision_codex |
| NOAEL | =10 mg/kg/day | - | - | developmental toxicity | SCCS_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for Hydroxyethoxy Aminopyrazolopyridine HCl across SCCS product categories, with measured dermal absorption where available.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.044% | - | - | SCCS/0150 |
| measured | 0.15% | - | - | SCCS/0150 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for Hydroxyethoxy Aminopyrazolopyridine HCl.
Public NOAEL study rows linked to Hydroxyethoxy Aminopyrazolopyridine HCl by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg/day, mg/kg bw/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.044% | - | - |
| 0.15% | - | - |
Hydroxyethoxy Aminopyrazolopyridine HCl has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Hydroxyethoxy Aminopyrazolopyridine HCl EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
Hydroxyethoxy Aminopyrazolopyridine HCl functions as: Hair dyeing (oxidative hair dye substance, code A161). It is classified as a cosmetic ingredient in our database. CAS number: 1079221-49-0.
The NOAEL (No Observed Adverse Effect Level) for Hydroxyethoxy Aminopyrazolopyridine HCl is =1.67 mg/kg bw/d based on a developmental toxicity study via oral route in human. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Hydroxyethoxy Aminopyrazolopyridine HCl also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Check Hydroxyethoxy Aminopyrazolopyridine HCl compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hydroxyethoxy Aminopyrazolopyridine HCl in your formulation.