NOAEL Studies Cosmetic Ingredient

Hydroxyethyl-2-Nitro-p-Toluidine NOAEL Studies

INCI: HYDROXYETHYL-2-NITRO-P-TOLUIDINE

CAS: 100418-33-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.04 mg/kg bw/d rat oral 90 day dermal absorption p.26
SCCS Opinion NOAEL =0.05 mg/kg bw/d rat oral 90 day dermal absorption p.26
SCCS Opinion NOAEL =45 mg/kg bw - - Chronic genotoxicity Ref.: 21 (submission I, ref 9) 3, p.15
SCCS Opinion NOAEL =45 mg/kg bw/day rat - 90-day dermal absorption p.21
SCCS Opinion NOAEL =45 mg/kg bw/day - - Chronic genotoxicity p.20
SCCS Opinion NOAEL =45 mg/kg bw/d rat oral 90 day dermal absorption p.26
SCCS Opinion NOAEL =90 mg/kg bw - - Chronic genotoxicity Ref.: 21 (submission I, ref 9) 3, p.15
SCCS Opinion NOAEL =90 mg/kg bw/day - - Chronic genotoxicity p.20
SCCS Opinion NOAEL =240 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.14
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =60 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb306; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/9108?documentUUID=7656cd6b-cc29-4d91-bc42-958ce3e398e2; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15821589:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_acb7ab4295d69d5368b442ab7980105b
ECHA NOAEL =90 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c026f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/9108?documentUUID=7656cd6b-cc29-4d91-bc42-958ce3e398e2; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15838374:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a0aa9ad70f065276cee4d59a5b77ffd
ECHA NOAEL =240 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c0271; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/9108?documentUUID=7656cd6b-cc29-4d91-bc42-958ce3e398e2; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=clinical biochemistry|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15842773:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c2b53302bd489767eda65f288fad9ba
Regulatory source 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 45 mg/kg bw/day rat oral 90-day - p.27
Regulatory source dermal absorption =0.04 mg/kg bw/d rat oral 90 day dermal absorption p.26
Regulatory source dermal absorption =0.05 mg/kg bw/d rat oral 90 day dermal absorption p.26
Regulatory source dermal absorption 45 mg/kg bw/day rat - 90-day dermal absorption p.21
Regulatory source dermal absorption =45 mg/kg bw/d rat oral 90 day dermal absorption p.26
Regulatory source genotoxicity 45 mg/kg bw - - Chronic genotoxicity p.15
Regulatory source genotoxicity 45 mg/kg bw/day - - Chronic genotoxicity p.20
Regulatory source genotoxicity 45 mg/kg bw/day rat oral 90-day genotoxicity p.27
Regulatory source genotoxicity 90 mg/kg bw - - Chronic genotoxicity p.15
Regulatory source genotoxicity 90 mg/kg bw/day - - Chronic genotoxicity p.20
Regulatory source repeated dose toxicity 240 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.14
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier KL22OLP94K UNII - - - chemical -