Moderate Cosmetic Ingredient NOAEL Data

Hydroxyethyl Imidazolidinone

INCI: HYDROXYETHYL IMIDAZOLIDINONE

CAS Number
3699-54-5
Function
Humectant, solvent, moisturizing agent in cosmetics
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA UNII: N0K8F6P8IF; not listed in 21 CFR prohibited/restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Hydroxyethyl Imidazolidinone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL >1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Do not confuse with imidazolidinyl urea (formaldehyde releaser). This compound is not a formaldehyde donor. Requires explicit distinction in CPSR documentation. WGK 1 (slightly water-hazardous). Combustible liquid at 75% aqueous solution.

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Concern Level: Moderate

Frequently Asked Questions

Is Hydroxyethyl Imidazolidinone safe in cosmetics?

Do not confuse with imidazolidinyl urea (formaldehyde releaser). This compound is not a formaldehyde donor. Requires explicit distinction in CPSR documentation. WGK 1 (slightly water-hazardous). Combustible liquid at 75% aqueous solution. The EU classifies Hydroxyethyl Imidazolidinone as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is Hydroxyethyl Imidazolidinone allowed in the EU?

Hydroxyethyl Imidazolidinone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyethyl Imidazolidinone do in cosmetics?

Hydroxyethyl Imidazolidinone functions as: Humectant, solvent, moisturizing agent in cosmetics. It is classified as a cosmetic ingredient in our database. CAS number: 3699-54-5.

What is the Margin of Safety for Hydroxyethyl Imidazolidinone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Hydroxyethyl Imidazolidinone?

The NOAEL (No Observed Adverse Effect Level) for Hydroxyethyl Imidazolidinone is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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