NOAEL Studies Cosmetic Ingredient

Hydroxyethyl-p-Phenylenediamine Sulfate NOAEL Studies

INCI: HYDROXYETHYL-P-PHENYLENEDIAMINE SULFATE

CAS: 93841-25-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.035 mg/kg bw rat oral - dermal absorption p.25
SCCS Opinion NOAEL =25 mg/kg bw rat oral 90 days NOAEL study p.10
SCCS Opinion NOAEL =25 mg/kg bw/day rat - sub-chronic repeated dose toxicity p.15
SCCS Opinion NOAEL =30 mg/kg/day - - developmental developmental toxicity p.20
SCCS Opinion NOAEL =30 mg/kg rat oral - dermal absorption p.23
SCCS Opinion NOAEL =30 mg/kg/day human - developmental developmental toxicity p.22
SCCS Opinion NOAEL =30 mg/kg bw/d rat oral - dermal absorption p.25
SCCS Opinion NOAEL =35 mg/kg bw rat oral 28-day developmental toxicity p.23
SCCS Opinion NOAEL =55 mg/kg bw/day rat - 90 days genotoxicity p.16
SCCS Opinion NOAEL =250 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.15
SCCS Opinion NOAEL =2000 mg/kg bw rat dermal 5 days NOAEL study p.14
SCCS Opinion NOAEL =2000 mg/kg bw - dermal 5 days NOAEL study p.16
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =30 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfcb6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23274/7/9/3?documentUUID=577718c6-0b5f-43c7-86b2-34fa156f9302; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15820806:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47e18bc1259e0db3118dbc3536e00250
ECHA NOAEL =35 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf71e4b0a7c65d1ce086; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23274/7/6/2?documentUUID=577718c6-0b5f-43c7-86b2-34fa156f9302; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15844792:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4c4c62b5fe4d9cae38639b87011b21f6
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =2.12 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632698:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_292090390a9a7c39d994f08b6ff7bb67
Regulatory source 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 25 mg/kg bw rat oral 90 days - p.10
Regulatory source - 2000 mg/kg bw rat dermal 5 days - p.14
Regulatory source - 2000 mg/kg bw - dermal 5 days - p.16
Regulatory source dermal absorption =0.035 mg/kg bw rat oral - dermal absorption p.25
Regulatory source dermal absorption =30 mg/kg rat oral - dermal absorption p.23
Regulatory source dermal absorption =30 mg/kg rat oral 28-day dermal absorption p.23
Regulatory source dermal absorption =30 mg/kg bw/d rat oral - dermal absorption p.25
Regulatory source dermal absorption =30 mg/kg bw/d rat oral 28-day dermal absorption p.25
Regulatory source developmental toxicity 30 mg/kg/day - - developmental developmental toxicity p.20
Regulatory source developmental toxicity 30 mg/kg/day rat oral 28-day developmental toxicity p.23
Regulatory source developmental toxicity 30 mg/kg/day human - developmental developmental toxicity p.22
Regulatory source developmental toxicity 35 mg/kg bw rat oral 28-day developmental toxicity p.23
Regulatory source developmental toxicity 250 mg/kg bw/day rat oral 28-day developmental toxicity p.23
Regulatory source genotoxicity 55 mg/kg bw/day rat - 90 days genotoxicity p.16
Regulatory source repeated dose toxicity 25 mg/kg bw/day rat - sub-chronic repeated dose toxicity p.15
Regulatory source repeated dose toxicity 250 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.15
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier L8W90PN89R UNII - - - chemical -