Hydroxygenistein

INCI: HYDROXYGENISTEIN

CAS Number
480-23-9 (3'-hydroxygenistein / orobol) ; CosIng lists without Annex provisions
Function
Antioxidant, humectant, skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Significant data gap with limited published toxicological data for cosmetic use; isoflavones have estrogenic activity and endocrine activity of hydroxylated derivatives requires evaluation; genotoxicity and repeat-dose dermal data not established.

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Concern Level: High

Frequently Asked Questions

Is Hydroxygenistein safe in cosmetics?

Significant data gap with limited published toxicological data for cosmetic use; isoflavones have estrogenic activity and endocrine activity of hydroxylated derivatives requires evaluation; genotoxicity and repeat-dose dermal data not established. The EU classifies Hydroxygenistein as "permitted". Safety rating: MODERATE.

Is Hydroxygenistein allowed in the EU?

Hydroxygenistein EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxygenistein do in cosmetics?

Hydroxygenistein functions as: Antioxidant, humectant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 480-23-9 (3'-hydroxygenistein / orobol) ; CosIng lists without Annex provisions.

What is the Margin of Safety for Hydroxygenistein?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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