Hydroxypropyl Methylcellulose (HPMC)
INCI: HYDROXYPROPYL METHYLCELLULOSE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hydroxypropyl Methylcellulose (HPMC). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2004 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 25000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3846 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 40000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 7700 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 6500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 8209 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 8364 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Widely used pharmaceutical excipient with excellent safety profile; trace propylene oxide residuals possible.
Regulatory Flags
Frequently Asked Questions
Is Hydroxypropyl Methylcellulose (HPMC) safe in cosmetics?
Widely used pharmaceutical excipient with excellent safety profile; trace propylene oxide residuals possible. The EU classifies Hydroxypropyl Methylcellulose (HPMC) as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Hydroxypropyl Methylcellulose (HPMC) allowed in the EU?
Hydroxypropyl Methylcellulose (HPMC) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxypropyl Methylcellulose (HPMC) do in cosmetics?
Hydroxypropyl Methylcellulose (HPMC) functions as: Film forming, viscosity controlling, binding, stabilising, emulsion stabilising. It is classified as a cosmetic ingredient in our database. CAS number: 9004-65-3.
What is the Margin of Safety for Hydroxypropyl Methylcellulose (HPMC)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Hydroxypropyl Methylcellulose (HPMC)?
The NOAEL (No Observed Adverse Effect Level) for Hydroxypropyl Methylcellulose (HPMC) is 2004 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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