Hydroxypropyltrimonium Hyaluronate

INCI: HYDROXYPROPYLTRIMONIUM HYALURONATE

CAS Number
1714127-68-0
Function
Film former, humectant, substantive agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA pre-market approval required. Not on prohibited or restricted ingredients list. VCRP data indicates 1,379 reported uses. Not an OTC active ingredient. CIR has placed this ingredient on the 2026 Priority List for future formal safety evaluation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydroxypropyltrimonium Hyaluronate is a cationic derivative of hyaluronic acid with enhanced substantivity, permitted without restrictions in EU and US. Read-across from 2023 CIR Hyaluronates Final Report supports safe use at typical industry practice levels of 0.01-1%.

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Concern Level: Low

Regulatory Flags

eu-unrestricted no-cir-review no-sccs-opinion humectant

Frequently Asked Questions

Is Hydroxypropyltrimonium Hyaluronate safe in cosmetics?

Hydroxypropyltrimonium Hyaluronate is a cationic derivative of hyaluronic acid with enhanced substantivity, permitted without restrictions in EU and US. Read-across from 2023 CIR Hyaluronates Final Report supports safe use at typical industry practice levels of 0.01-1%. The EU classifies Hydroxypropyltrimonium Hyaluronate as "permitted". Safety rating: GOOD.

Is Hydroxypropyltrimonium Hyaluronate allowed in the EU?

Hydroxypropyltrimonium Hyaluronate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypropyltrimonium Hyaluronate do in cosmetics?

Hydroxypropyltrimonium Hyaluronate functions as: Film former, humectant, substantive agent. It is classified as a Cosmetic Ingredient in our database. CAS number: 1714127-68-0.

What is the Margin of Safety for Hydroxypropyltrimonium Hyaluronate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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