Carmine (CI 75470)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Carmine (CI 75470). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Carmine (CI 75470) based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Carmine (CI 75470), relevant to systemic exposure and MoS calculations.
Source: CIR
Expert Verdict
Regulatory Flags
Frequently Asked Questions
Is Carmine (CI 75470) safe in cosmetics?
Carmine (CI 75470) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Is Carmine (CI 75470) allowed in the EU?
Carmine (CI 75470) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carmine (CI 75470) do in cosmetics?
Carmine (CI 75470) functions as: Deodorizer; Dye; Flavouring and nutrient. It is classified as a Cosmetic Ingredient in our database. CAS number: 1390-65-4.
What is the Margin of Safety for Carmine (CI 75470)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Carmine (CI 75470)?
The NOAEL (No Observed Adverse Effect Level) for Carmine (CI 75470) is 500 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Carmine (CI 75470) compliance across multiple jurisdictions:
Related Ingredients
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