Moderate Cosmetic Ingredient

Hydroxypyridinone

INCI: HYDROXYPYRIDINONE

CAS Number
13161-30-3 (2-pyridinol 1-oxide / 1-hydroxy-2(1H)-pyridinone) [^1_10]
Function
Antimicrobial / chelating agent — closely related to piroctone olamine (the olamine salt of hydroxypyridinone)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 1.0%
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR restriction; OTC dandruff monograph may apply if antidandruff claims are made

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

If used for preservation/antimicrobial function, Annex V limits apply in EU; GHS H315 (skin irritation) and H319 (eye irritation) noted; chelating properties may affect metal ion-dependent formulation stability.

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Concern Level: Moderate

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Hydroxypyridinone safe in cosmetics?

If used for preservation/antimicrobial function, Annex V limits apply in EU; GHS H315 (skin irritation) and H319 (eye irritation) noted; chelating properties may affect metal ion-dependent formulation stability. The EU classifies Hydroxypyridinone as "permitted". Safety rating: MODERATE.

Is Hydroxypyridinone allowed in the EU?

Hydroxypyridinone EU regulatory status: permitted. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxypyridinone do in cosmetics?

Hydroxypyridinone functions as: Antimicrobial / chelating agent — closely related to piroctone olamine (the olamine salt of hydroxypyridinone). It is classified as a cosmetic ingredient in our database. CAS number: 13161-30-3 (2-pyridinol 1-oxide / 1-hydroxy-2(1H)-pyridinone) [^1_10].

What is the Margin of Safety for Hydroxypyridinone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Hydroxypyridinone compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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