Also known as: EINECS 283-892-6, Indigofera tinctoria
INCI: INDIGOFERA TINCTORIA LEAF EXTRACT
Indigofera Tinctoria Leaf Extract (CAS 84775-63-3) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Hair Dyeing. Reported NOAEL =0.87 mg/kg bw in rat (SCCS Opinion); EU Regulation 1223/2009 status: restricted, max 25%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84775-63-3 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Indigofera Tinctoria Leaf Extract.
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10 study endpoints found for Indigofera Tinctoria Leaf Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS Opinion |
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS Opinion |
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS Opinion |
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS Opinion |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS Opinion |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Preliminary editorial summary for Indigofera Tinctoria Leaf Extract — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Indigofera Tinctoria Leaf Extract by CAS number or substance name.
Indigofera Tinctoria Leaf Extract has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Indigofera Tinctoria Leaf Extract EU regulatory status: restricted. Maximum allowed concentration: 25%. This is based on EU Regulation 1223/2009 and its amendments.
Indigofera Tinctoria Leaf Extract functions as: Skin Conditioning, Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 84775-63-3.
The NOAEL (No Observed Adverse Effect Level) for Indigofera Tinctoria Leaf Extract is =0.87 mg/kg bw based on a carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Indigofera Tinctoria Leaf Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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