Regulatory Status
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Safety Data
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Expert Verdict
Inositol (CAS 87-89-8 myo-inositol; 643-12-9 D-chiro-inositol) is a cyclohexyl polyol sugar alcohol functioning as a hair conditioning agent, humectant, and antistatic in cosmetics. The CIR Expert Panel issued its final safety assessment in December 2024, concluding Inositol is safe in cosmetics in the present practices of use and concentration; the EU has not restricted it under EC No. 1223/2009 (not listed in Annexes II, III, IV, V, or VI) and no SCCS opinion has been issued. The ingredient holds FDA GRAS status under 21 CFR 184.1370 for direct human food use and is mandated in infant formula under 21 CFR 107.100. Genotoxicity is negative across Ames test, yeast assay, and multiple QSAR predictions.
Regulatory Flags
Frequently Asked Questions
Is Inositol safe in cosmetics?
Inositol (CAS 87-89-8 myo-inositol; 643-12-9 D-chiro-inositol) is a cyclohexyl polyol sugar alcohol functioning as a hair conditioning agent, humectant, and antistatic in cosmetics. The CIR Expert Panel issued its final safety assessment in December 2024, concluding Inositol is safe in cosmetics in the present practices of use and concentration; the EU has not restricted it under EC No. 1223/2009 (not listed in Annexes II, III, IV, V, or VI) and no SCCS opinion has been issued. The ingredient holds FDA GRAS status under 21 CFR 184.1370 for direct human food use and is mandated in infant formula under 21 CFR 107.100. Genotoxicity is negative across Ames test, yeast assay, and multiple QSAR predictions. The EU classifies Inositol as "permitted". Safety rating: EXCELLENT.
Is Inositol allowed in the EU?
Inositol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Inositol do in cosmetics?
Inositol functions as: Cell signaling molecule, osmoprotectant, skin conditioner; key metabolite in Galactomyces Ferment Filtrate (Pitera); supports cellular osmotic balance. It is classified as a cosmetic ingredient in our database. CAS number: 87-89-8.
What is the Margin of Safety for Inositol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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