NOAEL Studies Cosmetic Ingredient

Isobutoxypropanol NOAEL Studies

INCI: ISOBUTOXYPROPANOL

CAS: 29387-86-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =0 mg/ m3 rat oral - developmental toxicity 1; 450; (2, p.36
CIR Safety Assessment NOAEL =0.047 g/kg/d rat oral 14-d repeated dose toxicity (18; 7; 10, p.33
CIR Safety Assessment NOAEL =0.5 g/kg/d rat oral 5 d repeated dose toxicity 0, 800, 910; 0; 047, p.33
CIR Safety Assessment NOAEL =1.76 mg/kg bw/day rabbit dermal 91 days NOAEL study 880; 9,13,36; 5, p.20
CIR Safety Assessment NOAEL =10 mg/kg bw/day rabbit dermal 91 days NOAEL study 5; 91; 2, p.20
CIR Safety Assessment NOAEL =91 mg/kg/day rat oral - oral toxicity 35; 1; (2, p.21
CIR Safety Assessment NOAEL =100 mg/kg bw/day rat oral 46 day repeated dose toxicity 2; 12; 46, p.18
CIR Safety Assessment NOAEL >100 mg/ kg bw/day rat - days 7-18 of gestation developmental toxicity 9,11,17; (100; 19, p.23
CIR Safety Assessment NOAEL =100 mg/kg bw/d rat oral - developmental toxicity 2; 1; 0, p.33
CIR Safety Assessment NOAEL =200 mg/m3 rat inhalation SUBCHRONIC repeated dose toxicity 1; (2; 2, p.20
CIR Safety Assessment NOAEL =320 mg/m3 rat inhalation SUBCHRONIC repeated dose toxicity 10; 1; (2, p.20
CIR Safety Assessment NOAEL =350 mg/kg bw rat oral - oral toxicity 411; 5; 91, p.21
CIR Safety Assessment NOAEL =400 mg/kg bw rat oral 14 days oral toxicity 10; 6; 14, p.18
CIR Safety Assessment NOAEL =450 mg/kg rat oral - oral toxicity 10; 1; (2, p.22
CIR Safety Assessment NOAEL =500 mg/kg/day rat oral - repeated dose toxicity 9; 11; 1,2, p.24
CIR Safety Assessment NOAEL >750 mg/kg rat oral 2-wk oral toxicity 11; 1; (2, p.18
CIR Safety Assessment NOAEL =880 mg/kg bw rat inhalation SUBCHRONIC repeated dose toxicity 320; 9; 1, p.20
CIR Safety Assessment NOAEL =1000 mg/kg bw rat oral 14 days repeated dose toxicity 6; 14; 0, 100, 200, p.18
CIR Safety Assessment NOAEL =3244 mg/m3 rat inhalation 11 days inhalation toxicity 10; (98; 8, p.19
CIR Safety Assessment NOAEL >3785 mg/m3 rat - 6 h/day NOAEL study 344; (244; 13,49, p.19
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=578; RecordID=ARPathway2016_1114; DatasetName=ARPathway2016; DTXSID=DTXSID6029755; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029755
NTP ICE skin irritation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation TER 6 kiloohms - Dermal - In Vitro; TER Corrosion sheet=Data_invitro; excel_row=4263; Record_ID=skin_irritation_invitro_2500; Data_Type=In Vitro; Formulation_ID=MIX784; Formulation_Name=Dowanol PNB; Mixture=Mixture; DTXSID=DTXSID6029755; Assay=TER Corrosion; Endpoint=TER; Response=6; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029755
NTP ICE skin irritation TER 7.1 kiloohms - Dermal - In Vitro; TER Corrosion sheet=Data_invitro; excel_row=4258; Record_ID=skin_irritation_invitro_2501; Data_Type=In Vitro; Formulation_ID=MIX784; Formulation_Name=Dowanol PNB; Mixture=Mixture; DTXSID=DTXSID6029755; Assay=TER Corrosion; Endpoint=TER; Response=7.1; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029755
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOAEL =350 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0debe4b0a676289de6d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Clinical Observation: Not reported|Body Weight Changes: decrease(slight)|Food Consumption: decrease(slight)|Water Consumption: decrease(slight)|Absolute Organ Weight: Liver increase, Kidney increase|Relative Organ Weight: Liver increase, Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=HESS:15638132:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b6a05db0ad84e8da17ab13f06b1866d0
Regulatory source 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 1.76 mg/kg bw/day rabbit dermal 91 days - p.20
Regulatory source - 10 mg/kg bw/day rabbit dermal 91 days - p.20
Regulatory source - >3785 mg/m3 rat - 6 h/day - p.19
Regulatory source developmental toxicity 0 mg/ m3 rat oral - developmental toxicity p.36
Regulatory source developmental toxicity >100 mg/ kg bw/day rat - days 7-18 of gestation developmental toxicity p.23
Regulatory source developmental toxicity <=100 mg/kg bw/d rat oral - developmental toxicity p.33
Regulatory source inhalation toxicity 3244 mg/m3 rat inhalation 11 days inhalation toxicity p.19
Regulatory source oral toxicity 91 mg/kg/day rat oral - oral toxicity p.21
Regulatory source oral toxicity 350 mg/kg bw rat oral - oral toxicity p.21
Regulatory source oral toxicity 400 mg/kg bw rat oral 14 days oral toxicity p.18
Regulatory source oral toxicity 450 mg/kg rat oral - oral toxicity p.22
Regulatory source oral toxicity >750 mg/kg rat oral 2-wk oral toxicity p.18
Regulatory source repeated dose toxicity 0.047 g/kg/d rat oral 14-d repeated dose toxicity p.33
Regulatory source repeated dose toxicity 0.5 g/kg/d rat oral 5 d repeated dose toxicity p.33
Regulatory source repeated dose toxicity 100 mg/kg bw/day rat oral 46 day repeated dose toxicity p.18
Regulatory source repeated dose toxicity 200 mg/m3 rat inhalation SUBCHRONIC repeated dose toxicity p.20
Regulatory source repeated dose toxicity 320 mg/m3 rat inhalation SUBCHRONIC repeated dose toxicity p.20
Regulatory source repeated dose toxicity 500 mg/kg/day rat oral - repeated dose toxicity p.24
Regulatory source repeated dose toxicity 880 mg/kg bw rat inhalation SUBCHRONIC repeated dose toxicity p.20
Regulatory source repeated dose toxicity 1000 mg/kg bw rat oral 14 days repeated dose toxicity p.18
Regulatory source repeated dose toxicity 3785 mg/m3 rat oral subchronic repeated dose toxicity p.33
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6X8776AP5Z UNII - - - mixture -