NOAEL Studies Cosmetic Ingredient

Isophorone Diamine NOAEL Studies

INCI: ISOPHORONE DIAMINE

CAS: 2855-13-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13122; Record_ID=skin_sensitization_invivo_3126; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6027503; Assay=LLNA; Endpoint=EC3; Response=1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=BASF personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6027503
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =50 mg/kg bw/day Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be105; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34503/7/9/3?documentUUID=ac6740d4-c55f-4133-896c-53c64039bef9; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15823319:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4219662254a26c06d1a78a984307a85f
ECHA NOAEL >75 mg/kg bw/day Rabbit oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be102; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34503/7/9/3?documentUUID=ac6740d4-c55f-4133-896c-53c64039bef9; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15823496:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e31fb60bf932a53d64a4c55a74749933
ECHA NOAEL =100 mg/kg bw/day Rat oral acute; 1 days acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb54e4b0a7c65d225b06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34503/7/6/2?documentUUID=ac6740d4-c55f-4133-896c-53c64039bef9; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=clinical signs|gross pathology|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15839826:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a87441876e31e049213dc0b9cc7092be
ECHA NOEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be108; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34503/7/9/3?documentUUID=ac6740d4-c55f-4133-896c-53c64039bef9; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15824931:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c07c246bf1958e7c9f700353e9b1eb27
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =0.073 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629763:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3989163198c6f6bdbb49c71214ae3417
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOAEL =60 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e13e4b0a676289df5a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Body Weight Changes: Weight gain decrease|Food Consumption: decrease|Water Consumption: decrease|Absolute Organ Weight: Kidney increase|Relative Organ Weight: Kidney increase|Histopathology: Kidney: Tubular basophilia Kidney: Tubular casts Kidney: Lymphiod foci; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638561:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ceae046289a991c00236f2ae33ce6db3
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X5WYA841BU UNII - - - mixture -