NOAEL Studies
Cosmetic Ingredient
Isopropyl Acetate NOAEL Studies
INCI: ISOPROPYL ACETATE
CAS: 108-21-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 50.6 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1471; Record_ID=acute_inhalation_1139; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2025478; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=50.6; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025478 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =3000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_710; row=4158; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropyl acetate; preferred_name=Isopropyl acetate; dtxsid=DTXSID2025478; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025478; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =6750 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_711; row=4157; data_type=In Vivo; mixture=Chemical; chemical_name=Isopropyl acetate; preferred_name=Isopropyl acetate; dtxsid=DTXSID2025478; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025478; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 39.6993783454885 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10806; RecordID=ERPathway2016_366; DatasetName=ERPathway2016; DTXSID=DTXSID2025478; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=39.6993783454885; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025478 |
| NTP_ICE_endocrine | ACC | 42.1445699661997 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10807; RecordID=ERPathway2016_366; DatasetName=ERPathway2016; DTXSID=DTXSID2025478; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=42.1445699661997; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025478 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10802; RecordID=ARPathway2016_505; DatasetName=ARPathway2016; DTXSID=DTXSID2025478; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025478 |
| NTP_ICE_endocrine | Model Score | 0.0152 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=10808; RecordID=ERPathway2016_366; DatasetName=ERPathway2016; DTXSID=DTXSID2025478; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0152; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025478 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =75190.3 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15516408:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_19ec741b8066565debc742ed0dc04ef6 |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =3064 | mg/kg bw/day | Rabbit | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/10/1?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15825624:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f263b16555ef6c45fae0a02484b39b56 |
| ToxValDB_ECHA_IUCLID | LOEC | =1462.03 | mg/m3 | Rat | inhalation | chronic; 94 days | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/6/3?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828341_15828342:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e7b466fd995e9c3ad18a45216c592ff8 |
| ToxValDB_ECHA_IUCLID | NOAEC | =2088.62 | mg/m3 | Mouse | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/6/3?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15829290:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_68a2f549b9a28e223bd85343f64d5cc3 |
| ToxValDB_ECHA_IUCLID | NOAEC | =2113.68 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/6/3?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15829438:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c5e6fc1b996cd3110a139fa592c69d3 |
| ToxValDB_ECHA_IUCLID | NOAEC | ~14662.1 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d189e4b0a7c65d22ef08; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/9/3?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820664:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_177bba6553c94eb9f6899c042353d8bd |
| ToxValDB_ECHA_IUCLID | NOAEL | =596 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6fb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/9/3?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821707:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf27671c94e3b079b21ad990c0487f7c |
| ToxValDB_ECHA_IUCLID | NOAEL | =700 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5601; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/9/2?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=P0: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15857924:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef5681055872cbec31c4ffec7c5d5bf7 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =227 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632874_15632875:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25d8312f89c9f71f749302e69acb95c5 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =275 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632874_15632875:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_359074a082e18d09d43f47c3a31807ba |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 1Y67AFK870 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1Y67AFK870"} |
| openFDA substances | FDA UNII substance identifier | 1Y67AFK870 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1Y67AFK870"} |
| openFDA substances | FDA UNII substance identifier | 1Y67AFK870 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1Y67AFK870"} |
| openFDA substances | FDA UNII substance identifier | 1Y67AFK870 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1Y67AFK870"} |