Is Isopropyl Acetate safe in cosmetics?
Isopropyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Isopropyl Acetate
Also known as: Acetic acid, 1-methylethyl ester, 4-02-00-00141, BRN 1740761, EINECS 203-561-1, FEMA No. 2926 (+6 more)
INCI: ISOPROPYL ACETATE
Isopropyl Acetate (CAS 108-21-4) is a cosmetic cosmetic ingredient functioning as Solvent, fragrance ingredient. Reported NOAEL =596 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 108-21-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isopropyl Acetate is classified GHS Danger (H225, H319, H336, H303, H305, H315, H320, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent, fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
propan-2-yl acetate
InChIKey
JMMWKPVZQRWMSS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — RIFM fragrance safety assessment completed; not prohibited under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Isopropyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =596 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =700 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarn
Hazard Statements
Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life
Short-term Exposure Effects
The substance may be irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0907
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Isopropyl acetate irritates the eyes and upper respiratory tract.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
305
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPROPYL ACETATE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Isopropyl Acetate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isopropyl Acetate by CAS number or substance name.
Studies
2
Lowest NOAEL
596 mg/kg bw/day
Highest NOAEL
700 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acetic acid, 1-methylethyl ester
4-02-00-00141
BRN 1740761
EINECS 203-561-1
FEMA No. 2926
Paracetat
Isopropyl (acetate d')
Isopropylacetaat
Isopropyle (acetate d')
Isopropylester kyseliny octove
UNII-1Y67AFK870
Chemical Function
Solvent
Fragrance
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
consumer_product; Europe
consumer_product; Europe
consumer_product; detected; Europe
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1608674
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOPROPYL ACETATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isopropyl Acetate allowed in the EU?
Isopropyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropyl Acetate do in cosmetics?
Isopropyl Acetate functions as: Solvent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 108-21-4.
What is the NOAEL for Isopropyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Isopropyl Acetate is =596 mg/kg bw/day based on a developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Isopropyl Acetate classified as hazardous under GHS?
Isopropyl Acetate carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Isopropyl Acetate used outside cosmetics?
Isopropyl Acetate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopropyl Acetate have different safety status in cosmetics vs industrial chemicals?
Isopropyl Acetate is classified GHS Danger (H225, H319, H336, H303, H305, H315, H320, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isopropyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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