Good Cosmetic Ingredient GHS Classified

Isopropyl Acetate

INCI: ISOPROPYL ACETATE

CAS Number
108-21-4
Function
Solvent, fragrance ingredient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — RIFM fragrance safety assessment completed; not prohibited under 21 CFR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; excl mark;warn
Hazard Statements
Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life
Short-term Exposure Effects
The substance may be irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Highly flammable; causes serious eye irritation; may cause drowsiness or dizziness via inhalation; repeated exposure may cause skin dryness and cracking.

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Isopropyl Acetate safe in cosmetics?

Highly flammable; causes serious eye irritation; may cause drowsiness or dizziness via inhalation; repeated exposure may cause skin dryness and cracking. The EU classifies Isopropyl Acetate as "permitted". Safety rating: GOOD.

Is Isopropyl Acetate allowed in the EU?

Isopropyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isopropyl Acetate do in cosmetics?

Isopropyl Acetate functions as: Solvent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 108-21-4.

What is the Margin of Safety for Isopropyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Isopropyl Acetate classified as hazardous under GHS?

Isopropyl Acetate carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Isopropyl Acetate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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