NOAEL Studies Cosmetic Ingredient

Isopropyl Cloprostenate NOAEL Studies

INCI: ISOPROPYL CLOPROSTENATE

CAS: 157283-66-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.015 mg/kg bw/d rat dermal 3-month dermal absorption p.32
SCCS Opinion NOAEL =0.1 mg/kg bw/day rat oral 28 days reproductive toxicity Ref.: Indrei et al, p.23
SCCS Opinion NOAEL =3 - rat oral chronic reproductive toxicity p.40
SCCS Opinion NOAEL =3.3 - rat oral Sub-chronic repeated dose toxicity p.22
SCCS Opinion NOAEL =2004 - rat oral Sub-chronic repeated dose toxicity p.22
Regulatory source 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption 0.015 mg/kg bw/d rat dermal 3-month dermal absorption p.32
Regulatory source repeated dose toxicity 3.3 - rat oral Sub-chronic repeated dose toxicity p.22
Regulatory source repeated dose toxicity 2004 - rat oral Sub-chronic repeated dose toxicity p.22
Regulatory source reproductive toxicity 0.1 mg/kg bw/day rat oral 28 days reproductive toxicity p.23
Regulatory source reproductive toxicity 3 - rat oral chronic reproductive toxicity p.40
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 765298537G UNII - - - chemical -