Poor Cosmetic Ingredient SCCS/CIR Reviewed

Isopropyl Cloprostenate

INCI: ISOPROPYL CLOPROSTENATE

CAS Number
157283-66-4
Function
Hair conditioning agent; eyelash/eyebrow growth stimulant; synthetic prostaglandin F2α analog
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status restricted
US Notes Not specifically prohibited under 21 CFR for cosmetics; however, pharmacological activity raises drug-cosmetic boundary questions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

sccs SCCS/1635/21 3 February 2022
Verdict: unknown

Expert Verdict

Isopropyl cloprostenate is a synthetic prostaglandin analog with pharmacological activity that may trigger drug-cosmetic classification concerns under US regulations despite not being explicitly prohibited.

⚠️
Concern Level: High

Frequently Asked Questions

Is Isopropyl Cloprostenate safe in cosmetics?

Isopropyl cloprostenate is a synthetic prostaglandin analog with pharmacological activity that may trigger drug-cosmetic classification concerns under US regulations despite not being explicitly prohibited. The EU classifies Isopropyl Cloprostenate as "permitted". Safety rating: POOR. This ingredient has been reviewed by sccs.

Is Isopropyl Cloprostenate allowed in the EU?

Isopropyl Cloprostenate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isopropyl Cloprostenate do in cosmetics?

Isopropyl Cloprostenate functions as: Hair conditioning agent; eyelash/eyebrow growth stimulant; synthetic prostaglandin F2α analog. It is classified as a cosmetic ingredient in our database. CAS number: 157283-66-4.

What is the Margin of Safety for Isopropyl Cloprostenate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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