NOAEL Studies
Cosmetic Ingredient
Isopropylidenediphenol Diglycidyl Ether (BADGE) NOAEL Studies
INCI: ISOPROPYLIDENEDIPHENOL DIGLYCIDYL ETHER
CAS: 1675-54-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =15 | mg/kg bw/day | Rat | oral: gavage | 730 days | chronic/long term toxicity | EFSA AFC - 2004 - OutputID 356 - organ weights - systemic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to 2,2-bis(4-hydroxyphenyl)propane bis(2,3-epoxypropyl)ether (Bisphenol A diglycidyl ether, BADGE) - doi:10.2903/j.efsa.2004.86 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =15 | mg/kg bw/day | Rat | oral: gavage | 730 days | chronic/long term toxicity | EFSA AFC - 2004 - OutputID 356 - organ weights - systemic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to 2,2-bis(4-hydroxyphenyl)propane bis(2,3-epoxypropyl)ether (Bisphenol A diglycidyl ether, BADGE) - doi:10.2903/j.efsa.2004.86 |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=6975; Record_ID=cancer_7232; Data_Type=WOE; Formulation_Name=Bisphenol A diglycidyl ether; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 86.91348115 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5652; RecordID=ARPathway2016_88; DatasetName=ARPathway2016; DTXSID=DTXSID6024624; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=86.91348115; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_endocrine | ACC | 88.41065159 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5653; RecordID=ARPathway2016_88; DatasetName=ARPathway2016; DTXSID=DTXSID6024624; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=88.41065159; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_endocrine | Model Score | 0.0243 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5654; RecordID=ARPathway2016_88; DatasetName=ARPathway2016; DTXSID=DTXSID6024624; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0243; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5655; RecordID=ARPathway2016_88; DatasetName=ARPathway2016; DTXSID=DTXSID6024624; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
NTP_ICE_skin_sensitization 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 22.2 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2392; Record_ID=skin_sensitization_invitro_581; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=22.2; Reported_Response_Unit=ug/mL; Response=22.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 18.27 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2391; Record_ID=skin_sensitization_invitro_581; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=18.27; Reported_Response_Unit=ug/mL; Response=18.27; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 9.001 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8266; Record_ID=skin_sensitization_invitro_2289; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=26.43948296; Reported_Response_Unit=uM; Conversion_Factor_Value=340.419; Conversion_Factor_Source=EPA Dashboard; Converted_Response=9.001; Converted_Response_Unit=ug/mL; Response=9.001; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 9.91 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8718; Record_ID=skin_sensitization_invitro_2415; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=9.91; Reported_Response_Unit=ug/mL; Response=9.91; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | CV70 | 25.92 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8717; Record_ID=skin_sensitization_invitro_2415; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=U-SENS; Endpoint=CV70; Reported_Response=25.92; Reported_Response_Unit=ug/mL; Response=25.92; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | CV75 | 36 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2394; Record_ID=skin_sensitization_invitro_581; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=h-CLAT; Endpoint=CV75; Reported_Response=36; Reported_Response_Unit=ug/mL; Response=36; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Depletion Cys | 42.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=347; Record_ID=skin_sensitization_invitro_110; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=42.5; Reported_Response_Unit=%; Response=42.5; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Depletion Cys | 74.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=360; Record_ID=skin_sensitization_invitro_114; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=74.8; Reported_Response_Unit=%; Response=74.8; Response_Unit=%; Reference=Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Depletion Lys | 1.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=345; Record_ID=skin_sensitization_invitro_110; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.1000000000000001; Reported_Response_Unit=%; Response=1.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Depletion Lys | 3.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=358; Record_ID=skin_sensitization_invitro_114; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=3.2; Reported_Response_Unit=%; Response=3.2; Response_Unit=%; Reference=Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 21.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=354; Record_ID=skin_sensitization_invitro_110; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=21.8; Reported_Response_Unit=%; Response=21.8; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 39 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=362; Record_ID=skin_sensitization_invitro_114; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=39; Reported_Response_Unit=%; Response=39; Response_Unit=%; Reference=Takenouchi personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | EC1.5 | 5 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5444; Record_ID=skin_sensitization_invitro_1277; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5; Reported_Response_Unit=uM; Response=5; Response_Unit=uM; Reference=Delaine et al. 2011; 21751775; 10.1021/tx200196s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | EC1.5 | 5.2 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5445; Record_ID=skin_sensitization_invitro_1276; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.2; Reported_Response_Unit=uM; Response=5.2; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | EC3 | 8.7 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5446; Record_ID=skin_sensitization_invitro_1276; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=8.6999999999999993; Reported_Response_Unit=uM; Response=8.7; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | EC3 | 1.5 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13004; Record_ID=skin_sensitization_invivo_2957; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=LLNA; Endpoint=EC3; Response=1.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | IC50 | 21.9 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5447; Record_ID=skin_sensitization_invitro_1276; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=21.9; Reported_Response_Unit=uM; Response=21.9; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | IC50 | 22 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5448; Record_ID=skin_sensitization_invitro_1277; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=22; Reported_Response_Unit=uM; Response=22; Response_Unit=uM; Reference=Delaine et al. 2011; 21751775; 10.1021/tx200196s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Imax | 12.6 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5449; Record_ID=skin_sensitization_invitro_1276; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=12.6; Reported_Response_Unit=Unitless; Response=12.6; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
| NTP_ICE_skin_sensitization | Imax | 13 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5450; Record_ID=skin_sensitization_invitro_1277; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024624; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13; Reported_Response_Unit=Unitless; Response=13; Response_Unit=Ratio; Reference=Delaine et al. 2011; 21751775; 10.1021/tx200196s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024624; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024624 |
ToxValDB_ECHA_IUCLID 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =750 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7151; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/9/2?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15861987:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_095522c93314a5bceffa6381beb7ca6d |
| ToxValDB_ECHA_IUCLID | LEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7151; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/9/2?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15862430:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1bbdfc60dd44c9aa358873e02a355917 |
| ToxValDB_ECHA_IUCLID | LOAEL | =540 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7157; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/9/2?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15858650:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57a5ed3469a6ede353e0867037a4345c |
| ToxValDB_ECHA_IUCLID | NOAEL | =15 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b381d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/8?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820097:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4b55cb19d49a59248a02c821d3bc7a9d |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b381d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/8?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820121:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_35c07a8509f78cb43c4544de598bdcd9 |
| ToxValDB_ECHA_IUCLID | NOEL | =2 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b381d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/8?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820098:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2385cede9b263528aaac1e55c0e68e6e |
| ToxValDB_ECHA_IUCLID | NOEL | =10 | mg/kg bw/day | Rat | dermal | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ee6e4b096bca877b86c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/6/4?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15826684:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3176a9fecd1d15677a81cb74186765ba |
| ToxValDB_ECHA_IUCLID | NOEL | =100 | mg/kg bw/day | Rat | dermal | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ee6e4b096bca877b86c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/6/4?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15826685:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed5241fd7186008bbeb5b778ba76bd1b |
| ToxValDB_ECHA_IUCLID | NOEL | =750 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7151; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22590/7/9/2?documentUUID=0672faf9-5529-4e34-a00a-a0cdace2701e; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15861611:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9ec93800e9d3758797388bd771dca6de |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =4.93 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630184:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9af39220d878683efaeee25544c1a4c5 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | F3XRM1NX4H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F3XRM1NX4H"} |
| openFDA substances | FDA UNII substance identifier | F3XRM1NX4H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F3XRM1NX4H"} |
| openFDA substances | FDA UNII substance identifier | F3XRM1NX4H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F3XRM1NX4H"} |
| openFDA substances | FDA UNII substance identifier | F3XRM1NX4H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C21H24O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"F3XRM1NX4H"} |