NOAEL Studies Cosmetic Ingredient

ISOSORBIDE NOAEL Studies

CAS: 652-67-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9018; row=9398; data_type=In Vivo; mixture=Chemical; chemical_name=Isosorbide; preferred_name=Isosorbide; dtxsid=DTXSID5046196; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5046196; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =24150 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_9019; row=9399; data_type=In Vivo; mixture=Chemical; chemical_name=Isosorbide; preferred_name=Isosorbide; dtxsid=DTXSID5046196; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5046196; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =4800 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae98e4b0a7c65d1ca097; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5661/7/6/2?documentUUID=cae518d7-1d20-4044-90ee-0a96d20f7d3e; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834344_15834345:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a46ff5641df8255e19714ecc2110f9e1
ToxValDB_ECHA_IUCLID NOEL =1200 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae98e4b0a7c65d1ca097; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5661/7/6/2?documentUUID=cae518d7-1d20-4044-90ee-0a96d20f7d3e; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834344_15834345:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1780573ca237ef4d8a7e14ce462f2a86
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier WXR179L51S UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WXR179L51S"}
openFDA substances FDA UNII substance identifier WXR179L51S UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WXR179L51S"}
openFDA substances FDA UNII substance identifier WXR179L51S UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WXR179L51S"}
openFDA substances FDA UNII substance identifier WXR179L51S UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WXR179L51S"}