Is ISOSORBIDE safe in cosmetics?
ISOSORBIDE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
ISOSORBIDE
Also known as: 5-19-03-00201, BRN 0080510, Devicoran, D-1,4:3,6-Dianhydroglucitol, 1,4-Dianhydrosorbitol (+14 more)
ISOSORBIDE (CAS 652-67-5) is a cosmetic cosmetic ingredient functioning as Humectant, Skin Conditioning. Reported NOAEL =4800 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 652-67-5 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(3S,3aR,6R,6aR)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3,6-diol
InChIKey
KLDXJTOLSGUMSJ-JGWLITMVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for ISOSORBIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =4800 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for ISOSORBIDE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
humectant
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ISOSORBIDE by CAS number or substance name.
Studies
1
Lowest NOAEL
4800 mg/kg bw/day
Highest NOAEL
4800 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
5-19-03-00201
BRN 0080510
Devicoran
D-1,4:3,6-Dianhydroglucitol
1,4-Dianhydrosorbitol
1,4:3,6-Dianhydrosorbitol
1,4:3,6-Dianhydro-D-sorbitol
EINECS 211-492-3
Hydronol
Ismotic
Isobide
(+)-D-Isosorbide
NSC 40725
Vascardin dinitrate
Isosorbida
Isosorbidum
UNII-WXR179L51S
Polysorb PS
Polysorb P
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ISOSORBIDE
ChEMBL ID
CHEMBL1200660
Max Phase
4
Adverse Event Associations
611
Frequently Asked Questions
Is ISOSORBIDE allowed in the EU?
ISOSORBIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ISOSORBIDE do in cosmetics?
ISOSORBIDE functions as: Humectant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 652-67-5.
What is the NOAEL for ISOSORBIDE?
The NOAEL (No Observed Adverse Effect Level) for ISOSORBIDE is =4800 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is ISOSORBIDE used outside cosmetics?
ISOSORBIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check ISOSORBIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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