NOAEL Studies Cosmetic Ingredient

Itaconic Acid NOAEL Studies

INCI: ITACONIC ACID

CAS: 97-65-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL ~300 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1bae84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14392/7/9/2?documentUUID=83d4660b-186d-465b-bcc0-f8c0bcc66be1; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15862011:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cbba33838a9fa260135354949aba970e
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce68f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14392/7/6/2?documentUUID=83d4660b-186d-465b-bcc0-f8c0bcc66be1; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15849089:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e263ce62c61f327685bd0930821a9514
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfdf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14392/7/9/3?documentUUID=83d4660b-186d-465b-bcc0-f8c0bcc66be1; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15823756:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c6d5a172e227d9c6aa04ed8af093156c
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfdf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14392/7/9/3?documentUUID=83d4660b-186d-465b-bcc0-f8c0bcc66be1; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15823799:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_296bd321af2d9b28a631042bad826a6b
ToxValDB_ECHA_IUCLID NOEL =1001 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8ee4b0a7c65d1ce682; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14392/7/6/2?documentUUID=83d4660b-186d-465b-bcc0-f8c0bcc66be1; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15848393:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ac242a7d563f42c79f7a60c3af08ec15
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =22.05 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633387:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2f3eb42e75cc215877d206eb3f16756
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier Q4516562YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q4516562YH"}
openFDA substances FDA UNII substance identifier Q4516562YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q4516562YH"}
openFDA substances FDA UNII substance identifier Q4516562YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q4516562YH"}
openFDA substances FDA UNII substance identifier Q4516562YH UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q4516562YH"}