Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Itaconic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 1001 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Low concern at typical cosmetic use levels; as an organic acid, it can be irritating at high concentrations or low pH; standard pH buffering precautions apply. Synthetic origin (can also be bio-derived via fermentation of sugars by Aspergillus terreus); unsaturated dicarboxylic acid; its polymers (e.g., sodium polyitaconate) are 100% naturally derived, biodegradable styling agents with non-tacky hold and excellent curl retention
Frequently Asked Questions
Is Itaconic Acid safe in cosmetics?
Low concern at typical cosmetic use levels; as an organic acid, it can be irritating at high concentrations or low pH; standard pH buffering precautions apply. Synthetic origin (can also be bio-derived via fermentation of sugars by Aspergillus terreus); unsaturated dicarboxylic acid; its polymers (e.g., sodium polyitaconate) are 100% naturally derived, biodegradable styling agents with non-tacky hold and excellent curl retention The EU classifies Itaconic Acid as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Itaconic Acid allowed in the EU?
Itaconic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Itaconic Acid do in cosmetics?
Itaconic Acid functions as: Antimicrobial; Buffering (pH control); Skin Conditioning; Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 97-65-4.
What is the Margin of Safety for Itaconic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Itaconic Acid?
The NOAEL (No Observed Adverse Effect Level) for Itaconic Acid is 1001 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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