Is Keratin Hydrolysate safe in cosmetics?
Keratin Hydrolysate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Keratin Hydrolysate
INCI: HYDROLYZED KERATIN
Keratin Hydrolysate (CAS 69430-36-0) is a cosmetic cosmetic ingredient functioning as Hair Conditioning, Skin Conditioning, Film Forming, Moisturizing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 69430-36-0 →
Auto-generated CPSR Part A draft with source citations
Function
Hair Conditioning, Skin Conditioning, Film Forming, Moisturizing
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR assessed as safe; animal-derived (wool, feather, porcine); human-hair origin restricted in EU unless hydrolyzed under specific acid conditions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Keratin Hydrolysate.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Keratin Hydrolysate, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: CIR
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Conditioner | 0.5–2 | 5 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
amino_acid
{"cas_number": "69430-36-0", "ingredient_class": "keratin_derivative", "source_origin": "animal", "molecular_weight_range_Da": "1000-10000", "amino_acid_composition_key": "cysteine_rich_keratin", "isoelectric_point": "5.0", "charge_at_pH_5_5": "zwitterionic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "excellent", "moisture_binding_capacity": "excellent",…
anti_pollution
{"cas_number": "69430-36-0", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibit…
baby_pediatric
{"cas_number": "69430-36-0", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "6", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Protein, hair/skin", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Protein fragments…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal", "acne_safe": "yes", "source": "Protein"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "10.0", "typical_concentration_pct": "5.0", "product_type": "Hair Mask", "function_at_concentration": "Intensive protein repair", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "35", "estimated_cost_per_kg_usd_high": "65", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "New Zealand/US", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "medium", "commodity_or_specialty": "specialty", "substitute_ingredients": "S…
dermal_absorption
{"molecular_weight_da": "Variable", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "low", "source": "CIR"}
hair_care
{"hair_function": "protein-treatment", "hair_type_suitability": "medium/coarse", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Binder
Film former
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Keratin Hydrolysate.
Regulatory Flags
animal-derived
film-forming
hair-repair
eu-source-restriction
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Keratin Hydrolysate allowed in the EU?
Keratin Hydrolysate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Keratin Hydrolysate do in cosmetics?
Keratin Hydrolysate functions as: Hair Conditioning, Skin Conditioning, Film Forming, Moisturizing. It is classified as a cosmetic ingredient in our database. CAS number: 69430-36-0.
Compliance Tools
Check Keratin Hydrolysate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Bifidobacterium Ferment Lysate
Excellent
Same category
Skin conditioning (maintains skin in ...
Elastin
Excellent
Same category
Skin Conditioning, Humectant, Film-Fo...
Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein
Good
Same category
Hair Conditioning
Edible Bird's Nest Extract
Good
Same category
Skin conditioning, moisturizing, anti...
Glutaminase
Good
Same category
Skin conditioning, enzyme catalyst
Collagen Amino Acids
Moderate
Same category
Humectant; Softener and conditioner
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Hydrogenated Poly(C6-20 Olefin)
Excellent
Chemical family
Viscosity controlling, abrasive
Hydrolyzed Hair Keratin
Good
Chemical family
Hair conditioning, skin conditioning
Hydrolyzed Keratin
Excellent
Chemical family
Nail Conditioning Agent, Hair Conditi...
Is Keratin Hydrolysate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Keratin Hydrolysate in your formulation.