NOAEL Studies Active Ingredient

L-Arginine NOAEL Studies

INCI: ARGININE

CAS: 74-79-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 50 mg/kg bw/day mouse oral 365 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 174 mg/kg bw/day rat oral 33 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =3.131 mg/kg bw/day Rat - 91 days subchronic EFSA FEEDAP - 2007 - OutputID 160 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product containing L-arginine produced by fermentation from Corynebacterium glutamicum (ATCC-13870) for all animal species - doi:10.2903/j.efsa.2007.473
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =3.131 mg/kg bw/day Rat - 91 days subchronic EFSA FEEDAP - 2007 - OutputID 160 - no adverse effect observed at single/highest dose - Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product containing L-arginine produced by fermentation from Corynebacterium glutamicum (ATCC-13870) for all animal species - doi:10.2903/j.efsa.2007.473
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =3.131 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA FEEDAP (2007). Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product containing L-arginine produced by fermentation from Corynebacterium glutamicum (ATCC-13870) for all animal species. doi:10.2903/j.efsa.2007.473.; TITLE=Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed on the safety and efficacy of the product containing L-arginine produced by fermentation from Corynebacterium glutamicum (ATCC-13870) for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2007.473; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614118:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9afe9daf93a45507166a71b909cfd8a3
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =552 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629873:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4aa4d13e9adb55a594d3d138a5a0e5f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 94ZLA3W45F UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"94ZLA3W45F"}
openFDA substances FDA UNII substance identifier 94ZLA3W45F UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"94ZLA3W45F"}
openFDA substances FDA UNII substance identifier 94ZLA3W45F UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"94ZLA3W45F"}
openFDA substances FDA UNII substance identifier 94ZLA3W45F UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"94ZLA3W45F"}