Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for L-Arginine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 174 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 50 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| dose_tested | 174 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 3130.9 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 3318 mg/kg bw/day | oral | rat | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of L-Arginine, relevant to systemic exposure and MoS calculations.
Source: J Cosmet Sci 2017
Expert Verdict
L-Arginine is the sole precursor for nitric oxide synthesis in skin with GRAS status from FDA and CIR safety confirmation. Ion-pair formulations demonstrate superior wound healing, barrier restoration, and elasticity improvement with no safety concerns at typical use levels.
Regulatory Flags
Frequently Asked Questions
Is L-Arginine safe in cosmetics?
L-Arginine is the sole precursor for nitric oxide synthesis in skin with GRAS status from FDA and CIR safety confirmation. Ion-pair formulations demonstrate superior wound healing, barrier restoration, and elasticity improvement with no safety concerns at typical use levels. The EU classifies L-Arginine as "permitted". Safety rating: EXCELLENT. 8 toxicological study endpoint(s) are available in our database.
Is L-Arginine allowed in the EU?
L-Arginine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Arginine do in cosmetics?
L-Arginine functions as: Nitric oxide precursor; improves microcirculation, nutrient delivery, wound healing, and barrier restoration. Ion-pair formulations with glutamic acid enhance percutaneous absorption.. It is classified as a Active Ingredient in our database. CAS number: 74-79-3.
What is the Margin of Safety for L-Arginine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Arginine?
The NOAEL (No Observed Adverse Effect Level) for L-Arginine is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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