NOAEL Studies Cosmetic Ingredient

L-Phenylalanine NOAEL Studies

INCI: PHENYLALANINE

CAS: 63-91-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 450 mg/kg bw/day mouse oral 600 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 820 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1300 mg/kg bw/day rat oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1500 mg/kg bw/day rat oral 28 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral NA Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7000 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOEL ~500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9d15; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33169/7/6/2?documentUUID=db5c2d21-761c-47c7-b450-a80e656a8fcb; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15833234:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1caff1b2daccf6b684255192dd43dbfd
ToxValDB_ECHA_IUCLID NOEL ~1500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9d15; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33169/7/6/2?documentUUID=db5c2d21-761c-47c7-b450-a80e656a8fcb; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15833235:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_490612349f0a7e3c82264632e5d54974
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 47E5O17Y3R UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"47E5O17Y3R"}
openFDA substances FDA UNII substance identifier 47E5O17Y3R UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"47E5O17Y3R"}
openFDA substances FDA UNII substance identifier 47E5O17Y3R UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"47E5O17Y3R"}
openFDA substances FDA UNII substance identifier 47E5O17Y3R UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"47E5O17Y3R"}