NOAEL Studies Cosmetic Ingredient

L-Tyrosine NOAEL Studies

INCI: TYROSINE

CAS: 60-18-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 618 mg/kg bw/day rat oral 1 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 8000 mg/kg bw/day rat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 6 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c97f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24422/7/6/2?documentUUID=3f989a82-cc2f-4cf4-ab4c-2a935c2ec3fb; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15834136:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c162d9d4a528a21c89da7c23c5af66fc
ToxValDB_ECHA_IUCLID NOAEL =600 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c97f8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24422/7/6/2?documentUUID=3f989a82-cc2f-4cf4-ab4c-2a935c2ec3fb; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15834137:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f1b52897b315b7dd56f5c672ac1dad9
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 42HK56048U UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42HK56048U"}
openFDA substances FDA UNII substance identifier 42HK56048U UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42HK56048U"}
openFDA substances FDA UNII substance identifier 42HK56048U UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42HK56048U"}
openFDA substances FDA UNII substance identifier 42HK56048U UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H11NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"42HK56048U"}