Moderate Cosmetic Ingredient NOAEL Data

Lactamide DEA

INCI: LACTAMIDE DEA

CAS Number
5422-34-4
Function
Emulsifier, humectant, surfactant
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted with CIR limitations — safe when formulated to be non-irritating; should not be used in products where N-nitroso compounds may form

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Lactamide DEA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=900 mg/kg bw/day oral rat oral REACH

Expert Verdict

DEA moiety can form carcinogenic nitrosamines with nitrosating agents; free DEA levels must be controlled; CIR recommends ≤5% in leave-on products for DEA-containing ingredients

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Concern Level: High

Regulatory Flags

ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Lactamide DEA safe in cosmetics?

DEA moiety can form carcinogenic nitrosamines with nitrosating agents; free DEA levels must be controlled; CIR recommends ≤5% in leave-on products for DEA-containing ingredients The EU classifies Lactamide DEA as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Lactamide DEA allowed in the EU?

Lactamide DEA EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lactamide DEA do in cosmetics?

Lactamide DEA functions as: Emulsifier, humectant, surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 5422-34-4.

What is the Margin of Safety for Lactamide DEA?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lactamide DEA?

The NOAEL (No Observed Adverse Effect Level) for Lactamide DEA is >=900 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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