NOAEL Studies Cosmetic Ingredient

Laevo-Rose Oxide NOAEL Studies

INCI: LAEVO-ROSE OXIDE

CAS: 16409-43-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 2.805 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =4300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_3193; row=3270; data_type=In Vivo; mixture=Chemical; chemical_name=4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran; preferred_name=4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran; dtxsid=DTXSID1051771; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771; source_file=acute_oral.xlsx
NTP ICE skin sensitization 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 2.55 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5731; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.55; Response_Unit=%; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Concentration, one positive response 1 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5727; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5720; Record_ID=skin_sensitization_invivo_1322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Incidence of positive responses 9.804 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5723; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=9.804; Response_Unit=%; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Induction dose per skin area 775 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5724; Record_ID=skin_sensitization_invivo_1324; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=775; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=IFF 1964: personal communication to RIFM|RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Induction dose per skin area 1350 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5718; Record_ID=skin_sensitization_invivo_1322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Induction dose per skin area 4650 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5732; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4650; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 2372 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5733; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2372; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Induction dose per skin area, one positive response 930 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5729; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=930; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5722; Record_ID=skin_sensitization_invivo_1322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771
ECHA 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL >2.51 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5246; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849169:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66f91e2f1662d787d1a69c34182c34ec
ECHA NOAEL >2.81 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5246; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849168:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8ca70695644fbd347b3649a4ef71b2ce
ECHA NOAEL =50 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/9/3?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824440:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_86c9a334e4cd450a483f0be9b931f0a4
ECHA NOAEL =100 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c524d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849171:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ee7ece9ff3a0b9d71393cecbf70a974
ECHA NOAEL =300 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c524d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849170:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b4a32a4659582f2c85a8cbd8dba4ac5
ECHA NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7129; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/9/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15862671:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bcaf5cd168a2b26cf9c5dd21f0ed0178
ECHA NOAEL =1152 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5249; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15848079:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ddecedc682efda0d1f4046054e9c4c56
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =1.2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635127:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec542f58e565435b61b2c0c0c6fb9b0d
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 4O51437J50 UNII - - - mixture -