Regulatory Status
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Safety Data
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Expert Verdict
Cytotoxic via NQO1-dependent ROS generation; potential skin irritant at higher concentrations; limited cosmetic safety data available; structurally related to lapachol with overlapping toxicity concerns. A cyclic ortho-naphthoquinone derived from lapachol; β-lapachone demonstrates potent NQO1-bioactivatable properties; the α-isomer (CAS 477-39-4) is less studied for cosmetic applications
Frequently Asked Questions
Is Lapachone safe in cosmetics?
Cytotoxic via NQO1-dependent ROS generation; potential skin irritant at higher concentrations; limited cosmetic safety data available; structurally related to lapachol with overlapping toxicity concerns. A cyclic ortho-naphthoquinone derived from lapachol; β-lapachone demonstrates potent NQO1-bioactivatable properties; the α-isomer (CAS 477-39-4) is less studied for cosmetic applications The EU classifies Lapachone as "permitted". Safety rating: MODERATE.
Is Lapachone allowed in the EU?
Lapachone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lapachone do in cosmetics?
Lapachone functions as: Skin conditioning, antioxidant (research-stage). It is classified as a cosmetic ingredient in our database. CAS number: 4707-32-8 (β-lapachone, the most common isomer).
What is the Margin of Safety for Lapachone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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