Larrea Tridentata Extract

INCI: LARREA TRIDENTATA EXTRACT

CAS Number
84603-69-0 (most commonly cited; not directly confirmed in search results)
Function
Antioxidant, skin conditioning
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes FDA listed as poisonous plant; NDGA removed from GRAS in 1968; FDA consumer warning issued in 1992.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Larrea tridentata extract carries highest concern due to documented hepatotoxicity from NDGA, FDA classification as poisonous plant, and inadequate dermal penetration safety data; cosmetic use requires full NDGA quantification, dermal penetration studies, and toxicological justification.

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Concern Level: High

Regulatory Flags

plant-extract natural-origin

Frequently Asked Questions

Is Larrea Tridentata Extract safe in cosmetics?

Larrea tridentata extract carries highest concern due to documented hepatotoxicity from NDGA, FDA classification as poisonous plant, and inadequate dermal penetration safety data; cosmetic use requires full NDGA quantification, dermal penetration studies, and toxicological justification. The EU classifies Larrea Tridentata Extract as "permitted". Safety rating: POOR.

Is Larrea Tridentata Extract allowed in the EU?

Larrea Tridentata Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Larrea Tridentata Extract do in cosmetics?

Larrea Tridentata Extract functions as: Antioxidant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84603-69-0 (most commonly cited; not directly confirmed in search results).

What is the Margin of Safety for Larrea Tridentata Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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