Good Cosmetic Ingredient NOAEL Data

Laureth-7

INCI: LAURETH-7

CAS Number
68439-50-9
Function
Nonionic surfactant – emulsifying agent, cleansing, detergent, wetting, dispersing, solubilizing
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — CIR-reviewed safe when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Laureth-7. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=500 mg/kg bw/day oral rat oral REACH
NOAEL >=150 mg/kg bw/day oral - oral REACH
NOAEL >=1000 mg/kg bw/day oral - oral REACH
NOAEL >=2000 mg/kg bw/day oral - oral REACH
NOAEL 750 mg/kg bw/day oral - oral REACH
NOAEL 100 mg/kg bw/day oral - oral REACH
NOAEL >=500 mg/kg bw/day oral rat oral REACH
NOAEL >=150 mg/kg bw/day oral - oral REACH
NOAEL >=1000 mg/kg bw/day oral - oral REACH
NOAEL >=2000 mg/kg bw/day oral - oral REACH

Expert Verdict

1,4-dioxane residual; can act as penetration enhancer for co-formulated ingredients; skin and eye irritation risk at high concentrations

⚠️
Concern Level: Moderate

Regulatory Flags

epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is Laureth-7 safe in cosmetics?

1,4-dioxane residual; can act as penetration enhancer for co-formulated ingredients; skin and eye irritation risk at high concentrations The EU classifies Laureth-7 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Laureth-7 allowed in the EU?

Laureth-7 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Laureth-7 do in cosmetics?

Laureth-7 functions as: Nonionic surfactant – emulsifying agent, cleansing, detergent, wetting, dispersing, solubilizing. It is classified as a cosmetic ingredient in our database. CAS number: 68439-50-9.

What is the Margin of Safety for Laureth-7?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Laureth-7?

The NOAEL (No Observed Adverse Effect Level) for Laureth-7 is >=500 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

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