NOAEL Studies Emollient

Lauric Acid NOAEL Studies

INCI: LAURIC ACID

CAS: 143-07-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 6.85427603139454 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8666; RecordID=ERPathway2016_134; DatasetName=ERPathway2016; DTXSID=DTXSID5021590; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=6.85427603139454; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_endocrine ACC 4.58105982043437 uM - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=8667; RecordID=ERPathway2016_134; DatasetName=ERPathway2016; DTXSID=DTXSID5021590; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=4.58105982043437; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8662; RecordID=ARPathway2016_849; DatasetName=ARPathway2016; DTXSID=DTXSID5021590; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_endocrine Model Score 0.017 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8669; RecordID=ERPathway2016_134; DatasetName=ERPathway2016; DTXSID=DTXSID5021590; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.017; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_eye_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1494; Record_ID=eye_irritation_107; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation 40 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Positive reaction 4.4 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1022; Record_ID=skin_irritation_invivo_6; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=4.40; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation TER 6.9 kiloohms - Dermal - In Vitro; TER Corrosion sheet=Data_invitro; excel_row=3489; Record_ID=skin_irritation_invitro_2506; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=TER Corrosion; Endpoint=TER; Response=6.9; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation TER 14.6 kiloohms - Dermal - In Vitro; TER Corrosion sheet=Data_invitro; excel_row=3490; Record_ID=skin_irritation_invitro_2507; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=TER Corrosion; Endpoint=TER; Response=14.6; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability 98.5 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=3503; Record_ID=skin_irritation_invitro_655; Data_Type=In Vitro; Formulation_Name=Lauric acid; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Irritation; Endpoint=Viability; Response=98.5; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability 99.8 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=3499; Record_ID=skin_irritation_invitro_644; Data_Type=In Vitro; Formulation_Name=Lauric acid; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Irritation; Endpoint=Viability; Response=99.8; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability 103.1 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=3501; Record_ID=skin_irritation_invitro_651; Data_Type=In Vitro; Formulation_Name=Lauric acid; Concentration=99.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Irritation; Endpoint=Viability; Response=103.1; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability 105.26 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=3502; Record_ID=skin_irritation_invitro_653; Data_Type=In Vitro; Formulation_Name=Lauric acid; Concentration=99.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Irritation; Endpoint=Viability; Response=105.26; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability 105.7 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=3500; Record_ID=skin_irritation_invitro_645; Data_Type=In Vitro; Formulation_Name=Lauric acid; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Irritation; Endpoint=Viability; Response=105.7; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (18 hours) 94 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=3495; Record_ID=skin_irritation_invitro_219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=94; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (240 minutes) 28.5 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3547; Record_ID=skin_irritation_invitro_1946; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (240 minutes); Response=28.5; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (240 minutes) 49.6 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3546; Record_ID=skin_irritation_invitro_1959; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (240 minutes); Response=49.6; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (240 minutes) 51.2 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3545; Record_ID=skin_irritation_invitro_1957; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (240 minutes); Response=51.2; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (240 minutes) 108.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3550; Record_ID=skin_irritation_invitro_1952; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=108.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (240 minutes) 120.8 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3548; Record_ID=skin_irritation_invitro_1948; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=120.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (240 minutes) 141.7 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3549; Record_ID=skin_irritation_invitro_1950; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=141.70; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 87.4 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3527; Record_ID=skin_irritation_invitro_1954; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=87.4; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 90.4 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3528; Record_ID=skin_irritation_invitro_1956; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=90.4; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 92 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3529; Record_ID=skin_irritation_invitro_1958; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=92; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 97.1 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3531; Record_ID=skin_irritation_invitro_1961; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=97.1; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 102 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3524; Record_ID=skin_irritation_invitro_1948; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=102; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 104 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3525; Record_ID=skin_irritation_invitro_1950; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=104; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 104.6 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3526; Record_ID=skin_irritation_invitro_1952; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=104.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 105.7 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3532; Record_ID=skin_irritation_invitro_1962; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=105.7; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 110.7 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3522; Record_ID=skin_irritation_invitro_1959; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=110.7; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 111.3 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3523; Record_ID=skin_irritation_invitro_1946; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=111.3; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 116 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3530; Record_ID=skin_irritation_invitro_1960; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (3 minutes); Response=116; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (3 minutes) 118.6 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3521; Record_ID=skin_irritation_invitro_1957; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=118.6; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (42 hours) 78.9 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=3497; Record_ID=skin_irritation_invitro_219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=78.9; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 21.9 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3540; Record_ID=skin_irritation_invitro_1956; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=21.9; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 22.7 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3539; Record_ID=skin_irritation_invitro_1954; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=22.7; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 31.5 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3541; Record_ID=skin_irritation_invitro_1958; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=31.5; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 34.3 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3544; Record_ID=skin_irritation_invitro_1962; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=34.30; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 34.6 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3542; Record_ID=skin_irritation_invitro_1960; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=34.6; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 44.3 % - Dermal - In Vitro; EpiDerm Corrosion sheet=Data_invitro; excel_row=3543; Record_ID=skin_irritation_invitro_1961; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiDerm Corrosion; Endpoint=Viability (60 minutes); Response=44.3; Response_Unit=%; Reference=Liebsch et al. 2000; 25419920; 10.1177/026119290002800309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 82.7 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3535; Record_ID=skin_irritation_invitro_1946; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=82.7; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 94.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3538; Record_ID=skin_irritation_invitro_1952; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=94.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 97.1 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3534; Record_ID=skin_irritation_invitro_1959; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=97.1; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 107.7 % - Dermal - In Vitro; SkinEthic Corrosion sheet=Data_invitro; excel_row=3533; Record_ID=skin_irritation_invitro_1957; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=107.7; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 111.5 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3537; Record_ID=skin_irritation_invitro_1950; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=111.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_irritation Viability (60 minutes) 117.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3536; Record_ID=skin_irritation_invitro_1948; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=117.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_sensitization 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5484; Record_ID=skin_sensitization_invivo_1277; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
NTP_ICE_skin_sensitization Relative reliability score 5 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=5487; Record_ID=skin_sensitization_invivo_1277; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID5021590; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=5; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021590; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021590
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =17.632 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632930:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e12325841ef2685b59ba1d4464d283f1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1160N9NU9U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1160N9NU9U"}
openFDA substances FDA UNII substance identifier 1160N9NU9U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1160N9NU9U"}
openFDA substances FDA UNII substance identifier 1160N9NU9U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1160N9NU9U"}
openFDA substances FDA UNII substance identifier 1160N9NU9U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1160N9NU9U"}