NOAEL Studies Cosmetic Ingredient

Lauroyl Sarcosine NOAEL Studies

INCI: LAUROYL SARCOSINE

CAS: 97-78-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
CIR Safety Assessment 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =30 mg/kg/day rat oral 28-day developmental toxicity 1; 85; (34, p.14
CIR Safety Assessment NOAEL =96.2 % rat oral 28-day developmental toxicity 30, 100; 250; 4, p.14
CIR Safety Assessment NOAEL =250 mg/kg/day - - - developmental toxicity 8; 11; 14, p.11
CIR Safety Assessment NOAEL =1000 mg/kg/day rat oral 6 months oral toxicity 2; 5; 1, p.10
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 42.07 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2976; Record_ID=adme_parameters_1212; Data_Type=Measured; DTXSID=DTXSID7042011; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=42.07; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042011
NTP ICE adme parameters Fu 0.003219 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2975; Record_ID=adme_parameters_1212; Data_Type=Measured; DTXSID=DTXSID7042011; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.003219; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042011
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12100; RecordID=ARPathway2016_1791; DatasetName=ARPathway2016; DTXSID=DTXSID7042011; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042011
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =141.053 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632932:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00d87180ddff05dda33bf28deb6d4ea2
Regulatory source 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 30 mg/kg/day rat oral 28-day developmental toxicity p.14
Regulatory source developmental toxicity 96.2 % rat oral 28-day developmental toxicity p.14
Regulatory source developmental toxicity >=250 mg/kg/day - - - developmental toxicity p.11
Regulatory source inhalation toxicity 250 mg/kg/day rat oral 3- month inhalation toxicity p.14
Regulatory source oral toxicity 1000 mg/kg/day rat oral 6 months oral toxicity p.10
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier LIJ19P3L6F UNII - - - chemical -