Moderate Cosmetic Ingredient NOAEL Data

Lauryl Methacrylate

INCI: LAURYL METHACRYLATE

CAS Number
142-90-5
Function
Film former; nail-enhancement monomer
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted. CIR concluded safe as used in nail enhancement products when skin contact is avoided.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Lauryl Methacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 120 mg/kg bw/day oral rat oral REACH
NOAEL 120 mg/kg bw/day oral - oral REACH

Expert Verdict

GHS H315/H319/H335 โ€” skin irritant, eye irritant, respiratory irritant. CIR restricts intended use to nail products only with avoidance of skin contact. Polymerizable monomer; must not be formulated for direct prolonged skin exposure. Aquatic toxicity: H410 (very toxic to aquatic life with long-lasting effects).

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Concern Level: Moderate

Regulatory Flags

ifra_fragrance

Frequently Asked Questions

Is Lauryl Methacrylate safe in cosmetics?

GHS H315/H319/H335 โ€” skin irritant, eye irritant, respiratory irritant. CIR restricts intended use to nail products only with avoidance of skin contact. Polymerizable monomer; must not be formulated for direct prolonged skin exposure. Aquatic toxicity: H410 (very toxic to aquatic life with long-lasting effects). The EU classifies Lauryl Methacrylate as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is Lauryl Methacrylate allowed in the EU?

Lauryl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lauryl Methacrylate do in cosmetics?

Lauryl Methacrylate functions as: Film former; nail-enhancement monomer. It is classified as a cosmetic ingredient in our database. CAS number: 142-90-5.

What is the Margin of Safety for Lauryl Methacrylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lauryl Methacrylate?

The NOAEL (No Observed Adverse Effect Level) for Lauryl Methacrylate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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