Regulatory Status
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Safety Data
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Expert Verdict
Significant - hepatotoxicity (boxed warning), negative inotropic effects (congestive heart failure risk), numerous drug-drug interactions via CYP3A4 inhibition; absolutely not appropriate for cosmetic formulation. Triazole-class antifungal; broad-spectrum activity against dermatophytes, yeasts, and molds; this ingredient appears in CosIng as a reference entry but its pharmaceutical classification precludes cosmetic use
Frequently Asked Questions
Is Itraconazole safe in cosmetics?
Significant - hepatotoxicity (boxed warning), negative inotropic effects (congestive heart failure risk), numerous drug-drug interactions via CYP3A4 inhibition; absolutely not appropriate for cosmetic formulation. Triazole-class antifungal; broad-spectrum activity against dermatophytes, yeasts, and molds; this ingredient appears in CosIng as a reference entry but its pharmaceutical classification precludes cosmetic use The EU classifies Itraconazole as "prohibited". Safety rating: MODERATE.
Is Itraconazole allowed in the EU?
Itraconazole EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Itraconazole do in cosmetics?
Itraconazole functions as: Antifungal agent (pharmaceutical active). It is classified as a cosmetic ingredient in our database. CAS number: 84625-61-6.
What is the Margin of Safety for Itraconazole?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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